Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
≥98% Purity
SARMsSKU: CP-T500
Tesofensine 500mcg
≥98% PuritySupplier batch spec; selected lots Janoshik-tested
Research Reference
peptidesdb.org
/p/tesofensine
€181.49In Stock
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Research-grade Tesofensine. ≥98% supplier batch specification; selected lots independently tested (99.3% avg across published reports). Oral capsules in sealed bottle. For laboratory research use only. Not for human consumption.
Volume PricingApplied automatically at checkout
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €181.49 | €181.49 | -- |
| 3+ | €172.42 | €517.25 | 5% off |
| 5+Most Popular | €163.34 | €816.71 | 10% off |
| 10+ | €154.27 | €1,542.67 | 15% off |
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Total: €181.49
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Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Purity HPLC
99.3% average HPLC purity, verified by independent third-party testing
Third-Party Tested
Janoshik report published when available
Fast Shipping
24h dispatch, EU-wide shipping from €4.99
Third-Party Tested
Supplier batch specification on every product; independent Janoshik report on selected lots
Last reviewed: 2026-06-05
About Tesofensine 500mcg
This compound was first investigated in the context of Parkinson disease research. The metabolic endpoint findings were an accident. NeuroSearch studied tesofensine in early-phase research, observed unremarkable neurological effects, and noticed unexpected substantial metabolic endpoint changes as a secondary finding. That result reoriented the research program. CAS: 402856-42-2. MW 395.9 Da. Tesofensine is a triple monoamine reuptake inhibitor — blocking serotonin, dopamine, and norepinephrine transporters simultaneously.
Mechanism
This is not incretin pharmacology. GLP-1 agonists work through hormonal receptor signaling. Tesofensine works through monoamine reuptake inhibition, and in research models this is studied across three systems at once: serotonergic signalling via hypothalamic 5-HT receptors, noradrenergic effects on sympathetic tone and thermogenesis, and dopaminergic modulation of reward circuits and food-seeking behaviour — neural rather than endocrine pathways.
The pharmacological overlap with sibutramine (the withdrawn dual SNRI) is real but shouldn't be overstated. Sibutramine's cardiovascular liability was specifically about sympathomimetic cardiovascular effects. Tesofensine has a distinct receptor affinity profile and different pharmacokinetics — worth distinguishing carefully in research design. Early-phase research data showed dose-dependent metabolic endpoint changes that caught the field's attention and drove the subsequent research interest in central mechanisms as an alternative to incretin pathways.
Specifications
| Molecular Weight | 395.9 Da |
|---|---|
| CAS | 402856-42-2 |
| Purity | ≥98% (supplier batch spec; 99.3% avg across independently tested lots) |
| Form | Capsule |
| Sizes | 500mcg (60 capsules) |
Storage: Room temperature, away from moisture and direct light.
Quality: Every product ships to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical (HPLC + mass spectrometry; 99.3% average purity across published reports), searchable by batch code at certapeptides.com/verify. EU-based QC under CERTALAB S.R.L.
Frequently Asked Questions
How does tesofensine's mechanism differ from GLP-1 agonists?
GLP-1 agonists work through hormonal receptor pathways — they mimic an incretin hormone and signal through the GLP-1 receptor to affect insulin, appetite, and gastric emptying. Tesofensine works centrally, blocking reuptake of three monoamines (serotonin, dopamine, norepinephrine) to modulate appetite circuits and metabolic rate through neural pathways in research models. The two mechanisms are independent, which is why they're sometimes studied in combination for additive effects.
Is tesofensine similar to sibutramine?
There's a pharmacological overlap — both inhibit monoamine reuptake — but the profiles differ. Sibutramine was a dual SNRI (serotonin and norepinephrine). Tesofensine adds dopamine reuptake inhibition and has a different receptor affinity profile overall. Sibutramine was withdrawn for cardiovascular reasons tied to sympathomimetic effects; tesofensine's cardiovascular profile in research contexts is different and should be evaluated on its own data rather than by analogy.
For research purposes only. Not for human consumption.
Specification Summary
Purity99.3% avg
FormLyophilized Powder
Storage-20\u00B0C
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, TCE Worldwide for all cross-border EU and non-EU markets (UK, Switzerland, Norway, Iceland, Israel, Serbia). Delivery 1–14 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
Frequently Asked
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