Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
≥98% PurityIn-House HPLC & MS Tested
GLP-1 and Incretin Research PeptidesSKU: CP-T500
Tesofensine 500mcg
≥99% PurityHPLC & MS verified
€150.99In Stock
Only 1left in stock — order soon
Delivers to EU in 7-10 business days
Free shipping over €200 · no customs paperwork (EU) · via EU carrier network
Research-grade Tesofensine. 99.3% avg purity, HPLC & MS verified. Oral tablets in sealed bottle. For laboratory research use only. Not for human consumption.
Volume PricingApplied automatically at checkout
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €150.99 | €150.99 | -- |
| 3+ | €143.44 | €430.32 | 5% off |
| 5+Most Popular | €135.89 | €679.46 | 10% off |
| 10+ | €128.34 | €1,283.42 | 15% off |
Earn 150 loyalty points with this purchase
1
Total: €150.99
Free shipping on orders over €200
Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Purity HPLC
99.3% average HPLC purity, verified by independent third-party testing
Third-Party Tested
Janoshik report published when available
Fast Shipping
24h dispatch, EU-wide shipping from €4.99
Third-Party Tested
Independent lab verification for every batch
Last reviewed: 2026-04-05
About Tesofensine 500mcg
This compound was developed for Parkinson disease. The metabolic endpoint research was an accident. NeuroSearch ran Phase 2 trials in Parkinson and Alzheimer subjects, observed unremarkable neurological effects, and noticed unexpected substantial metabolic endpoint changes as a secondary finding. That result reoriented the development program. CAS: 402856-42-2. MW 395.9 Da. Tesofensine is a triple monoamine reuptake inhibitor — blocking serotonin, dopamine, and norepinephrine transporters simultaneously.
Mechanism
This is not incretin pharmacology. GLP-1 agonists work through hormonal receptor signaling. Tesofensine works through monoamine reuptake inhibition: serotonin drives satiety via hypothalamic 5-HT receptors, norepinephrine increases sympathetic tone and thermogenesis, dopamine modulates reward circuits and food-seeking behavior. Three systems, all at once, through neural rather than endocrine pathways.
The pharmacological overlap with sibutramine (the withdrawn dual SNRI) is real but shouldn't be overstated. Sibutramine's cardiovascular liability was specifically about sympathomimetic cardiovascular effects. Tesofensine has a distinct receptor affinity profile and different pharmacokinetics — worth distinguishing carefully in research design. Phase 2b TIPO-1 trial data showed dose-dependent metabolic endpoint changes that caught the field's attention and drove the subsequent development interest in central mechanisms as an alternative to incretin pathways.
Specifications
| Molecular Weight | 395.9 Da |
|---|---|
| CAS | 402856-42-2 |
| Purity | 99.3% avg by HPLC |
| Form | Capsule |
| Sizes | 500mcg (60 capsules) |
Storage: Room temperature, away from moisture and direct light.
Quality: HPLC purity analysis, mass spec identity confirmation, endotoxin testing on every batch. COA ships with every order. EU-based QC under CERTALAB S.R.L.
Frequently Asked Questions
How does tesofensine's mechanism differ from GLP-1 agonists?
GLP-1 agonists work through hormonal receptor pathways — they mimic an incretin hormone and signal through the GLP-1 receptor to affect insulin, appetite, and gastric emptying. Tesofensine works centrally, blocking reuptake of three monoamines (serotonin, dopamine, norepinephrine) to modulate appetite circuits and metabolic rate through neural pathways. The two mechanisms are independent, which is why they're sometimes studied in combination for additive effects.
Is tesofensine similar to sibutramine?
There's a pharmacological overlap — both inhibit monoamine reuptake — but the profiles differ. Sibutramine was a dual SNRI (serotonin and norepinephrine). Tesofensine adds dopamine reuptake inhibition and has a different receptor affinity profile overall. Sibutramine was withdrawn for cardiovascular reasons tied to sympathomimetic effects; tesofensine's cardiovascular profile in research contexts is different and should be evaluated on its own data rather than by analogy.
For research purposes only. Not for human consumption.
Specification Summary
Purity99.3% avg
FormLyophilized Powder
Storage-20\u00B0C
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Every batch is independently verified by Janoshik Analytical (100,000+ verifications/month), Eurofins Scientific, and Analytical Sciences International. We publish every Certificate of Analysis.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI RO54451735, VAT-registered. SameDay for Romania, FanCourier for Central/Eastern EU, TCE Worldwide for the rest. 3–7 business days EU-wide.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
Frequently Asked
Research Library
Related Research Articles
Based on category & popularity
Researchers Also Studied
500mcgSAME FIELDGLP-1 and Incretin Research Peptides
KPV Oral Capsules 500mcg
KPV is a naturally occurring tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (alpha-MSH). It has been studied for its immunomodulatory signaling in gastrointestinal and immune biology research models. Alpha-MSH-derived immunomodulatory tripeptide Intestinal epithelial barrier and PepT1 transporter research NF-kB pathway modulation studies For research purposes only. Not for human consumption.
€257.99
SAME FIELDGLP-1 and Incretin Research Peptides
Semaglutide Oral Capsules
Oral Semaglutide capsules for research into GLP-1 receptor agonism via enteric delivery. Available in 3mg and 7mg formulations. Supplied at 99.3% avg purity (HPLC-verified), with a Certificate of Analysis for every batch. Key research areas: Oral peptide bioavailability and absorption kinetics GLP-1 receptor-mediated glucose homeostasis Enteric coating and SNAC co-formulation studies For research purposes only. Not for human consumption.
From€171.99
RESEARCHERS ALSO STUDIEDBundles
Retatrutide Research Starter Kit
Retatrutide 10mg + Bacteriostatic Water 5ml + syringe + storage vial + alcohol pads. Everything you need to begin research. For research purposes only.
€NaN
RESEARCHERS ALSO STUDIEDBundles
Tirzepatide Research Starter Kit
Tirzepatide 10mg + Bacteriostatic Water 5ml + syringe + storage vial + alcohol pads. Everything you need to begin research. For research purposes only.
€NaN
Tesofensine 500mcg€150.99
1