Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
Matrixyl 10mg
No lab report for this lot. The lab report shown for this size does not cover this lot.
Black Friday week sale, ends 8 November. Volume pricing still applies.
Free shipping on orders over €200
- If a product doesn't match the specification on its published COA, contact us with your batch number: we investigate against the lot's report and replace any product that fails it, at no cost to you.
- Contact us within 48 hours of delivery with photos of the outer box, inner packing, and any affected vials with labels legible. Confirmed transit damage is replaced at no cost to you.
No lab report for this lot. The lab report shown for this size does not cover this lot.
3–7 days most of the EU · 10–14 Nordics/Baltics
Standard EU from €4.99 (RO) · core EU GLS €17.99 · Nordics/Baltics €12.99–€15.99 · Dispatched within 1–2 business days · Free shipping over €200.00 · no customs paperwork (EU) · via EU carrier network
€200.00 away from free shipping over €200.00. Under that, standard EU shipping is €17.99 (GLS, most of the EU).
How Paysera and SEPA work
- Pay: send a manual SEPA transfer using the IBAN we email you, or, where checkout offers it for your address, approve a SEPA transfer in your own bank via Paysera's hosted page.
- We confirm — Paysera notifies us instantly, or we match a manual transfer when it arrives (usually 1 business day).
- We dispatch — confirmed orders typically ship within 1–2 business days.
Matrixyl (Palmitoyl Pentapeptide-4) is a synthetic matrikine composed of a pro-collagen I fragment linked to a palmitoyl chain for enhanced membrane penetration. Studied for stimulating extracellular matrix production. Supplied as lyophilized powder; class-level specification ≥98%. For research purposes only. Not for human consumption.
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €16.98 | €16.98 | -- |
| 3+ | €16.13 | €48.39 | 5% off |
| 5+Most Popular | €15.28 | €76.41 | 10% off |
| 10+ | €14.43 | €144.33 | 15% off |
Important Notice
This product is intended for research purposes only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Published laboratory reports are available for selected lots. Check each report for its result and stated method. For research purposes only.
Dispatched within 1–2 business days, shipping from €4.99 in Romania, from €12.99 across the rest of Europe
Class-level specification on record; independent Janoshik report on selected lots
About Matrixyl
Matrixyl is the trade name for palmitoyl pentapeptide-4 (Pal-KTTKS), a lipopeptide that emerged from wound-healing research in the early 2000s. The core sequence -- lysine-threonine-threonine-lysine-serine -- is a fragment of the procollagen I C-propeptide, and when palmitoylated it becomes membrane-permeable enough to reach dermal fibroblasts. That structural relationship to collagen's own signaling machinery is what drew cosmetic and dermatological researchers to it initially.
Research Context
In vitro, Pal-KTTKS upregulates collagen I, collagen III, and fibronectin synthesis in human dermal fibroblasts. The mechanism appears to involve TGF-beta-independent pathways, which is notable because most profibrotic signals run through TGF-beta and carry the risk of excess scarring. Whether this in vitro activity translates cleanly to in vivo outcomes is still being worked out -- the literature has some positive small trials and some results that are harder to interpret. The fatty acid tail matters for tissue penetration: without palmitoylation, the peptide stays largely at the surface.
Research applications include studies of extracellular matrix remodeling, fibroblast proliferation kinetics in cited models, and fibroblast behavior under aged conditions. Some groups have used Matrixyl to probe the signaling gap between procollagen processing and de novo synthesis initiation. Comparison with Matrixyl 3000 (a different pair: palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) is another active area.
Specifications
| Parameter | Value |
|---|---|
| Active compound | Palmitoyl pentapeptide-4 (Pal-KTTKS) |
| Quantity | 10mg lyophilized powder |
| Purity | ≥98% (class-level specification) |
| Molecular weight | 802.1 Da |
| Sequence | Pal-Lys-Thr-Thr-Lys-Ser |
| Form | Lyophilized powder |
| Certificate of Analysis | Available on request |
Storage
Store at -20°C, protected from light and moisture. Long-term storage at -20°C: 6–12+ months. Reconstitute in sterile water or PBS for laboratory use. Avoid repeated freeze-thaw cycles. Intended for research use by qualified personnel.
What distinguishes Matrixyl from other collagen-stimulating research compounds?
Its structural derivation from the procollagen C-propeptide is the key differentiator. Rather than acting as a generic growth factor stimulus, Pal-KTTKS mimics a native feedback signal that fibroblasts use to gauge collagen turnover. It also operates through TGF-beta-independent pathways, which is useful for research contexts where the standard profibrotic axis would confound results.
Does the palmitoyl group affect experimental handling?
Yes. The fatty acid tail makes the compound somewhat lipophilic, so reconstitution may require a small amount of DMSO or ethanol before aqueous dilution. For cell culture experiments, carrier concentrations should be kept low (under 0.1% DMSO) to avoid cytotoxic effects that could confound fibroblast assays. Vortexing briefly after dilution usually achieves good dispersion.
Matrixyl (Pal-KTTKS) is supplied for laboratory research. Not for human use. For research purposes only.
Specification Summary
About Matrixyl
Matrixyl is the trade name for palmitoyl pentapeptide-4 (Pal-KTTKS), a lipopeptide that emerged from wound-healing research in the early 2000s. The core sequence -- lysine-threonine-threonine-lysine-serine -- is a fragment of the procollagen I C-propeptide, and when palmitoylated it becomes membrane-permeable enough to reach dermal fibroblasts. That structural relationship to collagen's own signaling machinery is what drew cosmetic and dermatological researchers to it initially.
Research Context
In vitro, Pal-KTTKS upregulates collagen I, collagen III, and fibronectin synthesis in human dermal fibroblasts. The mechanism appears to involve TGF-beta-independent pathways, which is notable because most profibrotic signals run through TGF-beta and carry the risk of excess scarring. Whether this in vitro activity translates cleanly to in vivo outcomes is still being worked out -- the literature has some positive small trials and some results that are harder to interpret. The fatty acid tail matters for tissue penetration: without palmitoylation, the peptide stays largely at the surface.
Research applications include studies of extracellular matrix remodeling, fibroblast proliferation kinetics in cited models, and fibroblast behavior under aged conditions. Some groups have used Matrixyl to probe the signaling gap between procollagen processing and de novo synthesis initiation. Comparison with Matrixyl 3000 (a different pair: palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) is another active area.
Specifications
| Parameter | Value |
|---|---|
| Active compound | Palmitoyl pentapeptide-4 (Pal-KTTKS) |
| Quantity | 10mg lyophilized powder |
| Purity | ≥98% (class-level specification) |
| Molecular weight | 802.1 Da |
| Sequence | Pal-Lys-Thr-Thr-Lys-Ser |
| Form | Lyophilized powder |
| Certificate of Analysis | Available on request |
Storage
Store at -20°C, protected from light and moisture. Long-term storage at -20°C: 6–12+ months. Reconstitute in sterile water or PBS for laboratory use. Avoid repeated freeze-thaw cycles. Intended for research use by qualified personnel.
What distinguishes Matrixyl from other collagen-stimulating research compounds?
Its structural derivation from the procollagen C-propeptide is the key differentiator. Rather than acting as a generic growth factor stimulus, Pal-KTTKS mimics a native feedback signal that fibroblasts use to gauge collagen turnover. It also operates through TGF-beta-independent pathways, which is useful for research contexts where the standard profibrotic axis would confound results.
Does the palmitoyl group affect experimental handling?
Yes. The fatty acid tail makes the compound somewhat lipophilic, so reconstitution may require a small amount of DMSO or ethanol before aqueous dilution. For cell culture experiments, carrier concentrations should be kept low (under 0.1% DMSO) to avoid cytotoxic effects that could confound fibroblast assays. Vortexing briefly after dilution usually achieves good dispersion.
Matrixyl (Pal-KTTKS) is supplied for laboratory research. Not for human use. For research purposes only.
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every vial label carries a code. Look it up on our Verify page: it shows what CertaPeptides publishes for that code and, for a withdrawn lot, that the lot was withdrawn and why. If yours is withdrawn, or if the code on your label finds nothing, email us that code.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland). Delivery 1–15 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with escalation to ANPC and alternative dispute resolution (SAL) available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
