Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
Cyclic and Neuropeptide Research CompoundsSKU: CP-SMX
Semax
≥98% PuritySupplier batch spec; selected lots Janoshik-tested
Janoshik Verified
98.55% HPLC
5mg · Report #155232
Related PeptidesDB entry (same owner)
peptidesdb.org
/p/semax
Delivers to EU in 3-7 business days
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Size5mg
€32.49
1
Total: €32.49
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Semax is a synthetic heptapeptide analog of the adrenocorticotropic hormone fragment ACTH(4-7). It has been studied extensively for its neurotrophic and nootropic properties in various experimental models. ACTH(4-7) analog with enhanced metabolic stability Neurotrophic factor expression and BDNF pathway research CNS receptor binding markers and memory research models For research purposes only. Not for human consumption.
Volume PricingApplied automatically at checkout
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €32.49 | €32.49 | -- |
| 3+ | €30.87 | €92.60 | 5% off |
| 5+Most Popular | €29.24 | €146.21 | 10% off |
| 10+ | €27.62 | €276.17 | 15% off |
Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
Recommended: PBS · stable for 14 days at 2-8°C once mixed.
When This Product May Not Suit Your Research
- ⚠If your research requires oral administration — Semax is an intranasal peptide and degrades in the GI tract.
- ⚠If your study needs a compound with FDA regulatory history — Semax has no FDA regulatory pathway.
- ⚠If your protocol requires standardized dosing guidelines — no international consensus dosing exists for Semax.
Purity HPLC
99.4% average HPLC purity across our published lab reports
Janoshik Verified
View report #155232 on janoshik.com →
Fast Shipping
24h dispatch, EU-wide shipping from €4.99
Third-Party Tested
Supplier batch specification on every product; independent Janoshik report on selected lots
Last reviewed: 2026-07-23
About Semax
About Semax
Semax (CAS: 80714-61-0) is a synthetic heptapeptide derived from the ACTH(4-7) fragment (Met-Glu-His-Phe) with an appended Pro-Gly-Pro tripeptide sequence to enhance metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax retains the neurotrophic properties of the parent ACTH fragment while resisting rapid enzymatic degradation.
Mechanism of Action
Semax influences multiple neurotransmitter systems and neurotrophic pathways. It has been shown to upregulate brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in experimental models. The peptide modulates dopaminergic, serotonergic, and cholinergic neurotransmission. Research also indicates effects on gene expression patterns related to neuronal survival and plasticity, involving activation of signaling cascades including the MAPK/ERK pathway.
Published Research
- Gusev, E. I., et al. (2006). Neurotrophic effects of Semax in experimental cerebral ischemia models. Neuroscience and Behavioral Physiology. DOI: 10.1007/s11055-006-0034-0
- Eremin, K. O., et al. (2008). Semax effects on cognitive processes and neurotransmitter systems. Neuroscience and Behavioral Physiology. DOI: 10.1007/s11055-008-0037-y
Product Specifications
- Molecular Weight: 813.9 Da
- CAS Number: 80714-61-0
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (ACTH(4-7) analog)
- Purity: ≥98% (supplier batch spec; 99.4% avg across independently tested lots)
- Form: Lyophilized powder
- Storage: -20°C, protected from light
Shipped to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical (HPLC + mass spectrometry; 99.4% average purity across published reports), searchable by batch code at certapeptides.com/verify.
For research purposes only. Not for human consumption.
Specification Summary
FormLyophilized Powder
Storage-20\u00B0C
About Semax
About Semax
Semax (CAS: 80714-61-0) is a synthetic heptapeptide derived from the ACTH(4-7) fragment (Met-Glu-His-Phe) with an appended Pro-Gly-Pro tripeptide sequence to enhance metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax retains the neurotrophic properties of the parent ACTH fragment while resisting rapid enzymatic degradation.
Mechanism of Action
Semax influences multiple neurotransmitter systems and neurotrophic pathways. It has been shown to upregulate brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in experimental models. The peptide modulates dopaminergic, serotonergic, and cholinergic neurotransmission. Research also indicates effects on gene expression patterns related to neuronal survival and plasticity, involving activation of signaling cascades including the MAPK/ERK pathway.
Published Research
- Gusev, E. I., et al. (2006). Neurotrophic effects of Semax in experimental cerebral ischemia models. Neuroscience and Behavioral Physiology. DOI: 10.1007/s11055-006-0034-0
- Eremin, K. O., et al. (2008). Semax effects on cognitive processes and neurotransmitter systems. Neuroscience and Behavioral Physiology. DOI: 10.1007/s11055-008-0037-y
Product Specifications
- Molecular Weight: 813.9 Da
- CAS Number: 80714-61-0
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (ACTH(4-7) analog)
- Purity: ≥98% (supplier batch spec; 99.4% avg across independently tested lots)
- Form: Lyophilized powder
- Storage: -20°C, protected from light
Shipped to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical (HPLC + mass spectrometry; 99.4% average purity across published reports), searchable by batch code at certapeptides.com/verify.
For research purposes only. Not for human consumption.
What research shows
Selected peer-reviewed studies from the published literature. Each describes laboratory or preclinical findings and is attributed to the cited study, not to this product. For research use only — not medical guidance.
[1]
Neuroprotection (cerebral ischemia)
In a rat model of cerebral ischemia-reperfusion, Semax (ACTH(4-7)PGP) was associated with a protective brain protein-expression profile relative to untreated ischemic controls.
Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion. International Journal of Molecular Sciences (2021). PMID: 34201112[2]
Neurotrophic factor expression
In rat studies, Semax administration was linked to altered temporal dynamics of NGF and BDNF gene expression in the hippocampus, frontal cortex, and retina.
Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action. Journal of Molecular Neuroscience (2010). PMID: 19662538[3]
Neurotrophins under ischemia
In rats subjected to incomplete global ischemia, Semax and its C-terminal peptide PGP were associated with changes in neurotrophin and neurotrophin-receptor expression in the brain.
The effect of semax and its C-end peptide PGP on expression of the neurotrophins and their receptors in the rat brain during incomplete global ischemia. Molekuliarnaia Biologiia (2011). PMID: 22295573Citations are provided for research reference. CertaPeptides (CERTALAB S.R.L.) is a reseller, not a manufacturer, and makes no medical, therapeutic, or efficacy claims. Products are for laboratory research use only and are not for human or animal consumption.
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland, Iceland, Israel, Serbia). Delivery 1–15 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
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Combined Price
€169.96
Semax€32.49