Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
≥98% PurityIn-House HPLC & MS Tested
Melanocortin and Pigment Research PeptidesSKU: CP-MT2
MT-2 (Melanotan 2 Acetate)
≥99% PurityHPLC & MS verified
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Melanotan II (MT-2) is a synthetic cyclic heptapeptide analog of alpha-MSH with potent melanocortin receptor agonist activity. Binds MC1R, MC3R, MC4R, MC5R. Studied for melanogenesis and energy homeostasis. Supplied as 99.3% avg pure lyophilized powder with Certificate of Analysis. For research purposes only. Not for human consumption.
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| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €19.99 | €19.99 | -- |
| 3+ | €18.99 | €56.97 | 5% off |
| 5+Most Popular | €17.99 | €89.96 | 10% off |
| 10+ | €16.99 | €169.92 | 15% off |
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Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Purity HPLC
99.3% average HPLC purity, verified by independent third-party testing
Third-Party Tested
Janoshik report published when available
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Last reviewed: 2026-04-24
About MT-2 (Melanotan 2 Acetate)
Melanotan II (MT-2) is a synthetic cyclic analogue of alpha-MSH (alpha-melanocyte-stimulating hormone), a peptide derived from POMC (proopiomelanocortin). It is a potent, non-selective agonist at melanocortin receptors (MC1R through MC5R), with particularly strong activity at MC1R and MC4R. This broad agonism is responsible for both its well-known effects on skin pigmentation (via MC1R) and its controversial research history around sexual arousal and appetite modulation (via MC4R).
The pharmacology is worth understanding in some detail. MC1R is expressed on melanocytes and regulates melanin production -- MT-2 activates eumelanin synthesis, producing darker skin pigmentation without UV exposure. MC4R is expressed in the hypothalamus and plays roles in GLP-1 receptor-mediated signalling and sexual function -- activation produces satiety signaling and, notably, pro-erectile effects in male rodent models. MC3R has roles in energy homeostasis. MT-2 activates all of these nonselectively, which produces the compound's range of effects and also complicates research interpretation where receptor-specific effects need to be isolated.
MT-2 was developed at the University of Arizona from research aimed at creating a tanning compound that would reduce UV-related skin cancer risk. The broader melanocortin agonism effects became apparent during development. It has been studied in clinical trials for sexual dysfunction and has an approved derivative (bremelanotide/PT-141) for hypoactive sexual desire disorder in women.
Specifications
| Parameter | Value |
|---|---|
| Compound | Melanotan II acetate (cyclic alpha-MSH analogue) |
| Purity | 99.3% avg (HPLC verified) |
| Format | Lyophilized powder |
| Reconstitution | Bacteriostatic water |
| Storage | -20°C; 2-8°C after reconstitution, protect from light |
Storage
Store at -20°C and protect from light. MT-2 is light-sensitive. Refrigerate after reconstitution at 2-8°C and use within 28 days. Lyophilized powder is stable for 24+ months under proper storage.
What melanocortin receptors does MT-2 activate?
MT-2 is a non-selective melanocortin receptor agonist with activity at MC1R, MC3R, MC4R, and MC5R. MC1R mediates skin and hair pigmentation (activating eumelanin synthesis in melanocytes). MC3R and MC4R are expressed in the hypothalamus and have roles in energy homeostasis, appetite, and sexual function. MC4R activation is responsible for MT-2's pro-erectile effects in rodent models and its satiety effects. MC5R has roles in exocrine gland function. MT-2's lack of receptor selectivity is a key consideration for research design when receptor-specific effects need to be distinguished.
How does MT-2 relate to PT-141 (bremelanotide)?
PT-141 (bremelanotide) is a metabolite of MT-2 formed by removal of the cyclic structure, and it is the compound that received FDA approval (2019) for hypoactive sexual desire disorder in premenopausal women under the brand name Vyleesi. The approved clinical application is specifically the sexual arousal effect mediated by MC4R, not the tanning or other melanocortin effects. MT-2 is the research precursor that established the MC4R-mediated sexual arousal pharmacology that PT-141 was developed from.
What was the original research goal for MT-2?
MT-2 was developed at the University of Arizona in the 1980s-90s with the goal of creating a pharmacological tanning agent that would produce melanin synthesis without UV exposure, potentially reducing UV-related skin cancer risk. The pro-pigmentation effect via MC1R was the primary target. The broader melanocortin receptor agonism -- including the MC4R-mediated effects on sexual arousal and appetite -- was discovered during development and shifted the research direction significantly.
Melanotan II is supplied for laboratory research use only. Not approved for human use. Handle in compliance with institutional biosafety guidelines.
Specification Summary
Purity99.3% avg
FormLyophilized Powder
Storage-20\u00B0C
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Who actually tests this?
Every batch is independently verified by Janoshik Analytical (100,000+ verifications/month), Eurofins Scientific, and Analytical Sciences International. We publish every Certificate of Analysis.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI RO54451735, VAT-registered. SameDay for Romania, FanCourier for Central/Eastern EU, TCE Worldwide for the rest. 3–7 business days EU-wide.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
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