PT-141 10mg

About PT-141 10mg

What is PT-141?
PT-141 (bremelanotide) acts on central melanocortin signalling rather than on peripheral vasculature. That distinction matters mechanistically. PDE5 inhibitors act on blood flow to peripheral tissue -- a vascular, mechanical pathway. PT-141 activates melanocortin-3 and melanocortin-4 receptors in the hypothalamus, modulating arousal circuitry at the level of central nervous system signaling. Different pathway, different mechanism.

CAS: 189691-06-3. Bremelanotide is a centrally-acting melanocortin peptide that has been characterized for its MC3R/MC4R pharmacology.

Mechanism of Action

The melanocortin connection
PT-141 is a derivative of Melanotan II, but with narrower receptor selectivity. MT-II hits MC1R through MC5R and drives pigmentation, appetite, and sexual-arousal pathways all at once. PT-141 was engineered to focus primarily on MC3R/MC4R in the hypothalamic arousal circuitry, with minimal melanogenic activity. It is the difference between a shotgun and a rifle.

Mechanism
MC3R and MC4R agonism in hypothalamic nuclei. These receptors are part of the melanocortin system -- the same pathway that regulates appetite, energy balance, and pigmentation. The arousal-related component involves melanocortin-dopamine crosstalk in reward circuitry. Notably, there is no nitric oxide or PDE5 involvement, which is why PT-141 acts through a completely different mechanism than the PDE5-inhibitor compound class.

Research Overview

Specs

Molecular weight1,025.2 Da
CAS189691-06-3
Purity≥98% supplier batch spec; 99.3% avg across independently tested lots
FormLyophilized powder
Sizes10mg

Storage
Lyophilized at -20°C. Reconstituted: 2-8°C, use within 4 weeks.

Quality
Shipped to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical (HPLC + mass spectrometry; 99.3% average purity across published reports), searchable by batch code at certapeptides.com/verify. EU QC under CERTALAB S.R.L.

Product Specifications

• Purity: ≥98% (supplier batch spec; 99.3% avg across independently tested lots)
• Form: Lyophilized powder
• SKU: CP-P41

Selected lots are independently tested by Janoshik Analytical, searchable by batch code at certapeptides.com/verify. View reports →

For research purposes only. Not for human consumption.