Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
MT-1 10mg
3–7 days most of the EU · 8–14 Nordics/Baltics
Standard EU from €4.99 (RO) · core EU GLS €17.99 · Nordics/Baltics €12.99–€13.99 · Same-day dispatch before 14:00 CET on weekdays · Free shipping over €200 · no customs paperwork (EU) · via EU carrier network
€200.00 away from free shipping over €200. Under that, standard EU shipping is €17.99 (GLS, most of the EU).
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Research-grade MT-1. ≥98% supplier batch specification; selected lots independently tested. Lyophilized powder in sealed glass vial. For laboratory research use only. Not for human consumption.
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €27.99 | €27.99 | -- |
| 3+ | €26.59 | €79.77 | 5% off |
| 5+Most Popular | €25.19 | €125.96 | 10% off |
| 10+ | €23.79 | €237.92 | 15% off |
Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Published laboratory reports are available for selected lots. Check each report for its result and stated method. For research purposes only.
View report #212162 on janoshik.com →
24h dispatch, EU-wide shipping from €4.99
Supplier batch specification on every product; independent Janoshik report on selected lots
About MT-1 10mg
Melanotan I (afamelanotide) is a linear synthetic analogue of alpha-MSH with high selectivity for MC1R (melanocortin-1 receptor) compared to Melanotan II. The selectivity distinction is pharmacologically significant: In research models, MT-1 primarily activates MC1R on melanocytes, driving eumelanin synthesis (melanocyte pigmentation), without the pronounced MC4R-mediated effects (e.g. arousal and broader melanocortin pathways studied in animal models) that characterize MT-2. For research isolating melanocyte biology and MC1R pharmacology from other melanocortin receptor effects, MT-1 is the more appropriate tool.
Afamelanotide has been characterized extensively in the literature: the linear alpha-MSH analogue has been studied for its MC1R-mediated photoprotective pharmacology in research models of erythropoietic protoporphyria (EPP), a photosensitivity phenotype linked to a heme synthesis defect. In such models, afamelanotide's MC1R-mediated melanin increase has been investigated as a route to photoprotection. This body of pharmacology research provides unusually complete characterization data for a research peptide.
Each vial contains 10mg.
Specifications
| Parameter | Value |
|---|---|
| Compound | Melanotan I (afamelanotide, linear alpha-MSH analogue) |
| Amount per Vial | 10mg |
| Purity | ≥98% (supplier batch spec) |
| Format | Lyophilized powder |
| Reconstitution | Bacteriostatic water |
| Storage | -20°C; 2-8°C after reconstitution, protect from light |
Storage
Store at -20°C and protect from light. Refrigerate after reconstitution at 2-8°C and use within 28 days. Stable for 24+ months as lyophilized powder under proper conditions.
What is the key difference between MT-1 and MT-2?
MT-1 (afamelanotide) is a linear alpha-MSH analogue with preferential selectivity for MC1R, the melanocyte receptor that drives skin pigmentation. MT-2 (Melanotan II) is a cyclic analogue that is a non-selective melanocortin receptor agonist with significant activity at MC1R, MC3R, MC4R, and MC5R. The MC4R activity of MT-2 produces pro-erectile and appetite-suppressing effects in animal models that MT-1 largely lacks. For research specifically on melanocyte biology, photoprotection, or MC1R pharmacology, MT-1 is the more appropriate compound. For studying MC4R or mixed melanocortin receptor effects, MT-2 is used.
What is erythropoietic protoporphyria and how is MT-1 studied in that context?
Erythropoietic protoporphyria (EPP) is a rare genetic disorder caused by deficient ferrochelatase activity, leading to accumulation of protoporphyrin IX in red blood cells and skin. When protoporphyrin IX absorbs UV light, it generates reactive oxygen species that drive phototoxicity. In research on this pathway, MT-1 (afamelanotide) increases eumelanin through MC1R activation, which absorbs UV light before it reaches photosensitizing protoporphyrin molecules. This melanin-shield mechanism is the basis for studying afamelanotide as a photoprotective tool compound in EPP research models.
Is MT-1 the same as afamelanotide used in research?
Yes, Melanotan I and afamelanotide refer to the same compound. Afamelanotide is the INN (International Nonproprietary Name) used in regulatory contexts, while "Melanotan I" or "MT-1" is the commonly used research name. The compound is the same linear alpha-MSH analogue regardless of the name used. The implant formulation delivers it as a subcutaneous bioresorbable depot; research applications use the reconstituted solution.
Melanotan I is supplied for laboratory research use only. Not approved for general human use. Handle in compliance with institutional biosafety guidelines.
Specification Summary
About MT-1 10mg
Melanotan I (afamelanotide) is a linear synthetic analogue of alpha-MSH with high selectivity for MC1R (melanocortin-1 receptor) compared to Melanotan II. The selectivity distinction is pharmacologically significant: In research models, MT-1 primarily activates MC1R on melanocytes, driving eumelanin synthesis (melanocyte pigmentation), without the pronounced MC4R-mediated effects (e.g. arousal and broader melanocortin pathways studied in animal models) that characterize MT-2. For research isolating melanocyte biology and MC1R pharmacology from other melanocortin receptor effects, MT-1 is the more appropriate tool.
Afamelanotide has been characterized extensively in the literature: the linear alpha-MSH analogue has been studied for its MC1R-mediated photoprotective pharmacology in research models of erythropoietic protoporphyria (EPP), a photosensitivity phenotype linked to a heme synthesis defect. In such models, afamelanotide's MC1R-mediated melanin increase has been investigated as a route to photoprotection. This body of pharmacology research provides unusually complete characterization data for a research peptide.
Each vial contains 10mg.
Specifications
| Parameter | Value |
|---|---|
| Compound | Melanotan I (afamelanotide, linear alpha-MSH analogue) |
| Amount per Vial | 10mg |
| Purity | ≥98% (supplier batch spec) |
| Format | Lyophilized powder |
| Reconstitution | Bacteriostatic water |
| Storage | -20°C; 2-8°C after reconstitution, protect from light |
Storage
Store at -20°C and protect from light. Refrigerate after reconstitution at 2-8°C and use within 28 days. Stable for 24+ months as lyophilized powder under proper conditions.
What is the key difference between MT-1 and MT-2?
MT-1 (afamelanotide) is a linear alpha-MSH analogue with preferential selectivity for MC1R, the melanocyte receptor that drives skin pigmentation. MT-2 (Melanotan II) is a cyclic analogue that is a non-selective melanocortin receptor agonist with significant activity at MC1R, MC3R, MC4R, and MC5R. The MC4R activity of MT-2 produces pro-erectile and appetite-suppressing effects in animal models that MT-1 largely lacks. For research specifically on melanocyte biology, photoprotection, or MC1R pharmacology, MT-1 is the more appropriate compound. For studying MC4R or mixed melanocortin receptor effects, MT-2 is used.
What is erythropoietic protoporphyria and how is MT-1 studied in that context?
Erythropoietic protoporphyria (EPP) is a rare genetic disorder caused by deficient ferrochelatase activity, leading to accumulation of protoporphyrin IX in red blood cells and skin. When protoporphyrin IX absorbs UV light, it generates reactive oxygen species that drive phototoxicity. In research on this pathway, MT-1 (afamelanotide) increases eumelanin through MC1R activation, which absorbs UV light before it reaches photosensitizing protoporphyrin molecules. This melanin-shield mechanism is the basis for studying afamelanotide as a photoprotective tool compound in EPP research models.
Is MT-1 the same as afamelanotide used in research?
Yes, Melanotan I and afamelanotide refer to the same compound. Afamelanotide is the INN (International Nonproprietary Name) used in regulatory contexts, while "Melanotan I" or "MT-1" is the commonly used research name. The compound is the same linear alpha-MSH analogue regardless of the name used. The implant formulation delivers it as a subcutaneous bioresorbable depot; research applications use the reconstituted solution.
Melanotan I is supplied for laboratory research use only. Not approved for general human use. Handle in compliance with institutional biosafety guidelines.
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland, Iceland, Serbia). Delivery 1–15 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
