Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
≥98% PurityIn-House HPLC & MS Tested
Copper and Mitochondrial Research PeptidesSKU: CP-F410
FOXO4 10mg
≥99% PurityHPLC & MS verified
€171.99Out of Stock
Delivers to EU in 7-10 business days
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Research-grade FOXO4. 99.3% avg purity, HPLC & MS verified. Lyophilized powder in sealed glass vial. For laboratory research use only. Not for human consumption.
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MADE TO ORDER — Expected delivery: ~3 weeks
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Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Purity HPLC
99.3% average HPLC purity, verified by independent third-party testing
Third-Party Tested
Janoshik report published when available
Fast Shipping
24h dispatch, EU-wide shipping from €4.99
Third-Party Tested
Independent lab verification for every batch
Last reviewed: 2026-03-26
About FOXO4 10mg
About FOXO4 10mg
What is FOXO4-DRI?
Senescent cells — the ones that have stopped dividing but refuse to die — stay alive by sequestering p53 in the nucleus through a FOXO4-p53 interaction. FOXO4-DRI disrupts that interaction. When the partnership breaks, p53 is free to do what it normally does in damaged cells: trigger apoptosis. The senescent cell dies. The healthy cell next door, which does not depend on FOXO4-p53 for survival, is unaffected.
Peter de Keizer at Erasmus University published this mechanism in 2017. It was the first peptide-based senolytic — a compound that selectively kills senescent cells.
Mechanism of Action
The D-retro-inverso trick
DRI stands for D-retro-inverso. All the amino acids are D-form (mirror image of natural L-amino acids) and the sequence runs backwards. This makes the peptide invisible to proteases — enzymes that normally chop up peptides cannot recognize D-amino acid substrates. So FOXO4-DRI has the binding specificity of the natural FOXO4 sequence but the metabolic stability that natural peptides lack.
Mechanism
Competes with endogenous FOXO4 for p53 binding. In senescent cells, FOXO4 keeps p53 trapped in the nucleus and away from the mitochondria where it would trigger apoptosis. FOXO4-DRI outcompetes this interaction, releasing p53. Free p53 translocates to mitochondria and initiates the intrinsic apoptosis pathway. Only cells that depend on FOXO4-p53 for survival are affected — which is specifically senescent cells.
Research Overview
Specs
Molecular weight~5,500 Da
CASN/A
Purity99.3% avg by HPLC
FormLyophilized powder
Sizes10mg
Storage
Lyophilized at -20°C. Reconstituted: 2-8°C, use within 4 weeks.
Quality
HPLC, mass spec, endotoxin testing. COA included. EU QC under CERTALAB S.R.L.
Product Specifications
- Purity: 99.3% avg (HPLC verified)
- Form: Lyophilized powder
- SKU: CP-F410
Certificate of Analysis available for every batch. View COAs →
For research purposes only. Not for human consumption.
Specification Summary
Purity99.3% avg
FormLyophilized Powder
Storage-20\u00B0C
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Every batch is independently verified by Janoshik Analytical (100,000+ verifications/month), Eurofins Scientific, and Analytical Sciences International. We publish every Certificate of Analysis.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI RO54451735, VAT-registered. SameDay for Romania, FanCourier for Central/Eastern EU, TCE Worldwide for the rest. 3–7 business days EU-wide.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
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