Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
Epitalon
This report covers the 50mg lot. Other sizes ship to our supplier batch specification.
Purity is high at 99.604%, but this vial assayed 44.05 mg against a 50 mg label — an 11.9% underfill, the largest in this package. A second sub-lot of the same batch (CP-2607-EPI50-B) has not been tested.
3–7 days most of the EU · 8–14 Nordics/Baltics
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Epitalon is a 4-amino acid synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase activation and telomere biology research. Derived from pineal gland epithalamin. Shipped to a ≥98% supplier batch specification; selected lots independently tested. Key research areas: Telomerase reactivation and telomere elongation in somatic cells Pineal gland neuroendocrine function and melatonin regulation Cellular aging and geroprotective mechanisms For research purposes only. Not for human consumption.
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €32.99 | €32.99 | -- |
| 3+ | €31.34 | €94.02 | 5% off |
| 5+Most Popular | €29.69 | €148.46 | 10% off |
| 10+ | €28.04 | €280.41 | 15% off |
Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
Recommended: BAC water · stable for 21 days at 2-8°C once mixed.
When This Product May Not Suit Your Research
- ⚠If your research requires a compound with Phase III clinical trial data — Epitalon's evidence base is primarily preclinical and early-phase.
- ⚠If your study design needs rapid-onset activity — Epitalon's proposed telomerase effects develop over extended treatment periods.
- ⚠If your lab requires a compound with well-characterized pharmacokinetics — Epitalon's PK profile is not fully established.
Published laboratory reports are available for selected lots. Check each report for its result and stated method. For research purposes only.
This report covers the 50mg lot. Other sizes ship to our supplier batch specification.
24h dispatch, EU-wide shipping from €4.99
Supplier batch specification on every product; independent Janoshik report on selected lots
About Epitalon
About Epitalon
Epitalon (CAS 307297-39-8), also known as Epithalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG). It was synthesized based on the amino acid composition of epithalamin, a polypeptide extract derived from the bovine pineal gland. Over 25 years of published research have characterized its telomere-related, neuroendocrine, and antioxidant properties in both in vitro and in vivo models.
Mechanism of Action
Epitalon has been shown to reactivate the catalytic subunit of telomerase (hTERT) in telomerase-negative human somatic cells, leading to measurable telomere elongation. Research demonstrates dose-dependent telomere length extension through both telomerase upregulation and alternative lengthening of telomeres pathways. Additionally, epitalon modulates pineal gland function by upregulating melatonin biosynthesis enzymes, restoring circadian melatonin rhythms that decline with age.
Published Research
- Telomerase induction: Epitalon reactivated telomerase gene expression and enzymatic activity in human fetal fibroblast cultures, inducing telomere elongation in cells that normally lack telomerase. (DOI)
- Neuroendocrine restoration: Administration to aged rhesus monkeys restored nighttime melatonin levels, reduced basal glucose and insulin. (DOI)
- Comprehensive bioactivity: A systematic review confirmed significant telomere-related and neuroendocrine effects originating from antioxidant, neurotrophic, and antimutagenic activity. (DOI)
Product Specifications
- Purity: ≥98% (supplier batch spec)
- Form: Lyophilized powder
- CAS: 307297-39-8
- Molecular Weight: 390.3 Da
Shipped to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical, searchable by batch code at certapeptides.com/verify. Verify a batch →
For research purposes only. Not for human consumption.
Specification Summary
About Epitalon
About Epitalon
Epitalon (CAS 307297-39-8), also known as Epithalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG). It was synthesized based on the amino acid composition of epithalamin, a polypeptide extract derived from the bovine pineal gland. Over 25 years of published research have characterized its telomere-related, neuroendocrine, and antioxidant properties in both in vitro and in vivo models.
Mechanism of Action
Epitalon has been shown to reactivate the catalytic subunit of telomerase (hTERT) in telomerase-negative human somatic cells, leading to measurable telomere elongation. Research demonstrates dose-dependent telomere length extension through both telomerase upregulation and alternative lengthening of telomeres pathways. Additionally, epitalon modulates pineal gland function by upregulating melatonin biosynthesis enzymes, restoring circadian melatonin rhythms that decline with age.
Published Research
- Telomerase induction: Epitalon reactivated telomerase gene expression and enzymatic activity in human fetal fibroblast cultures, inducing telomere elongation in cells that normally lack telomerase. (DOI)
- Neuroendocrine restoration: Administration to aged rhesus monkeys restored nighttime melatonin levels, reduced basal glucose and insulin. (DOI)
- Comprehensive bioactivity: A systematic review confirmed significant telomere-related and neuroendocrine effects originating from antioxidant, neurotrophic, and antimutagenic activity. (DOI)
Product Specifications
- Purity: ≥98% (supplier batch spec)
- Form: Lyophilized powder
- CAS: 307297-39-8
- Molecular Weight: 390.3 Da
Shipped to a ≥98% supplier batch specification; selected lots are independently tested by Janoshik Analytical, searchable by batch code at certapeptides.com/verify. Verify a batch →
For research purposes only. Not for human consumption.
What research shows
Selected peer-reviewed studies from the published literature. Each describes laboratory or preclinical findings and is attributed to the cited study, not to this product. For research use only — not medical guidance.
Telomerase and telomere biology
In cell-culture studies of human somatic cells, Epitalon (Epithalon) was reported to induce telomerase activity and telomere elongation.
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine (2003). PMID: 12937682Lifespan and aging research
In female rat models exposed to different illumination regimes, the Ala-Glu-Asp-Gly peptide (Epitalon) was studied for its effects on life span and the development of spontaneous tumors.
Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes. Bulletin of Experimental Biology and Medicine (2007). PMID: 18856211Pineal gland and melatonin
In pinealocyte cell-culture research, Epitalon-type pineal peptides were examined for molecular-cellular mechanisms regulating melatonin synthesis.
Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture. Bulletin of Experimental Biology and Medicine (2012). PMID: 22816096Citations are provided for research reference. CertaPeptides (CERTALAB S.R.L.) is a reseller, not a manufacturer, and makes no medical, therapeutic, or efficacy claims. Products are for laboratory research use only and are not for human or animal consumption.
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland, Iceland, Serbia). Delivery 1–15 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
