Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
Adipotide
No lab report for this lot.
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No lab report for this lot.
3–7 days most of the EU · 10–14 Nordics/Baltics
Standard EU from €4.99 (RO) · core EU GLS €17.99 · Nordics/Baltics €12.99–€15.99 · Dispatched within 1–2 business days · Free shipping over €200.00 · no customs paperwork (EU) · via EU carrier network
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Research-grade Adipotide. Class-level specification ≥98%. Lyophilized powder in sealed glass vial. For research purposes only. Not for human consumption.
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €39.99 | €39.99 | -- |
| 3+ | €37.99 | €113.97 | 5% off |
| 5+Most Popular | €35.99 | €179.95 | 10% off |
| 10+ | €33.99 | €339.92 | 15% off |
Important Notice
This product is intended for research purposes only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Due to legal and regulatory requirements, this product cannot be shipped to: Croatia, Czechia, Finland, Italy, Lithuania, and Slovenia.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Published laboratory reports are available for selected lots. Check each report for its result and stated method. For research purposes only.
Janoshik report published when available
Dispatched within 1–2 business days, shipping from €4.99 in Romania, from €12.99 across the rest of Europe
Class-level specification on record; independent Janoshik report on selected lots
About Adipotide
For research purposes only. Not for human or veterinary use.
Overview
Adipotide (also written as FTPP, or by its sequence CKGGRAKDC-GG-D(KLAKLAK)2) is a proapoptotic peptidomimetic built for vascular targeting of white adipose tissue. Two functional halves are joined in a single molecule: a homing peptide, CKGGRAKDC, that binds prohibitin displayed on the endothelium of blood vessels feeding white fat, and a proapoptotic domain, D(KLAKLAK)2, that disrupts mitochondrial membranes once it is internalised. The homing sequence was originally isolated through in vivo phage-display screening for peptides that localise to white adipose tissue vasculature, which is what gives the conjugate its tissue selectivity in research models.
The molecule was characterised by researchers at the University of Texas MD Anderson Cancer Center. It is frequently discussed as a conceptual parallel to antibody-drug conjugates: the cytotoxic payload is only delivered where the targeting element has bound, so activity is concentrated at the intended vascular bed rather than distributed systemically. CertaPeptides is a reseller and supplies Adipotide as a research reagent; we do not manufacture, formulate, or select the salt form of this compound.
Research Areas
Published literature has investigated Adipotide primarily as a tool for studying adipose-tissue vascular biology and the metabolic consequences of ablating fat-feeding vasculature. In the foundational mouse work, targeted ablation of adipose vasculature was used to study adipose-tissue remodelling and established prohibitin on adipose endothelium as an addressable target (Kolonin et al., 2004). A later non-human primate study examined tissue selectivity, metabolic parameters and renal markers (Barnhart et al., 2011). These two datasets remain the most cited reference points for researchers modelling vascular-targeting approaches to adipose tissue. Typical research questions include how selective prohibitin targeting is across different vascular beds, how model organisms respond to adipose vascular ablation, and how the conjugate format governs where apoptosis is triggered.
Specifications
| Compound | Adipotide / CKGGRAKDC-GG-D(KLAKLAK)2 |
|---|---|
| Purity | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Sterile water or PBS |
| Storage | −20°C lyophilized; 2–8°C after reconstitution, use within 14 days |
Quality & Verification
The class-level specification on record is ≥98%. No independent report is on record for this product yet; independent reports on selected lots are searchable by batch or report code at certapeptides.com/verify. We make no in-house testing claim and do not test every batch. EU-based handling under CERTALAB S.R.L.
Frequently Asked Questions
What is adipotide used for in research?
In the published literature, adipotide is used as a research tool to study vascular targeting of white adipose tissue. It combines a peptide that homes to prohibitin on adipose-feeding blood vessels with a proapoptotic domain, letting researchers investigate what happens in model systems when that specific vasculature is ablated. It is supplied for laboratory research only and is not for human or veterinary use.
How does adipotide target fat tissue specifically?
The CKGGRAKDC portion of the molecule was identified through in vivo phage-display screening for peptides that home to white adipose tissue vasculature. Its target, prohibitin, is displayed on the endothelium of fat-feeding vessels. Once the homing peptide binds, the D(KLAKLAK)2 domain is internalised and disrupts mitochondrial membranes, so activity is concentrated at the targeted vascular bed rather than distributed broadly.
What did the primate study report?
Barnhart and colleagues (2011, Science Translational Medicine) studied adipotide in rhesus monkeys, reporting on tissue selectivity, metabolic parameters and renal markers in the model animals. This primate dataset is the most advanced preclinical reference point cited for the compound.
What is a proapoptotic peptide-drug conjugate?
It is a molecule that pairs a targeting peptide with a cell-death-inducing payload, conceptually similar to an antibody-drug conjugate. In adipotide, the targeting peptide delivers the D(KLAKLAK)2 domain to adipose endothelial cells; the payload only acts where the targeting element has bound, which is the source of the conjugate's selectivity in research models.
How should adipotide be stored?
Store the lyophilized powder at −20°C, protected from light. After reconstitution with sterile water or PBS, keep refrigerated at 2–8°C and use within roughly 14 days. Handle in line with standard peptide-handling and institutional biosafety guidelines.
For research purposes only. Not for human consumption.
Specification Summary
About Adipotide
For research purposes only. Not for human or veterinary use.
Overview
Adipotide (also written as FTPP, or by its sequence CKGGRAKDC-GG-D(KLAKLAK)2) is a proapoptotic peptidomimetic built for vascular targeting of white adipose tissue. Two functional halves are joined in a single molecule: a homing peptide, CKGGRAKDC, that binds prohibitin displayed on the endothelium of blood vessels feeding white fat, and a proapoptotic domain, D(KLAKLAK)2, that disrupts mitochondrial membranes once it is internalised. The homing sequence was originally isolated through in vivo phage-display screening for peptides that localise to white adipose tissue vasculature, which is what gives the conjugate its tissue selectivity in research models.
The molecule was characterised by researchers at the University of Texas MD Anderson Cancer Center. It is frequently discussed as a conceptual parallel to antibody-drug conjugates: the cytotoxic payload is only delivered where the targeting element has bound, so activity is concentrated at the intended vascular bed rather than distributed systemically. CertaPeptides is a reseller and supplies Adipotide as a research reagent; we do not manufacture, formulate, or select the salt form of this compound.
Research Areas
Published literature has investigated Adipotide primarily as a tool for studying adipose-tissue vascular biology and the metabolic consequences of ablating fat-feeding vasculature. In the foundational mouse work, targeted ablation of adipose vasculature was used to study adipose-tissue remodelling and established prohibitin on adipose endothelium as an addressable target (Kolonin et al., 2004). A later non-human primate study examined tissue selectivity, metabolic parameters and renal markers (Barnhart et al., 2011). These two datasets remain the most cited reference points for researchers modelling vascular-targeting approaches to adipose tissue. Typical research questions include how selective prohibitin targeting is across different vascular beds, how model organisms respond to adipose vascular ablation, and how the conjugate format governs where apoptosis is triggered.
Specifications
| Compound | Adipotide / CKGGRAKDC-GG-D(KLAKLAK)2 |
|---|---|
| Purity | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Sterile water or PBS |
| Storage | −20°C lyophilized; 2–8°C after reconstitution, use within 14 days |
Quality & Verification
The class-level specification on record is ≥98%. No independent report is on record for this product yet; independent reports on selected lots are searchable by batch or report code at certapeptides.com/verify. We make no in-house testing claim and do not test every batch. EU-based handling under CERTALAB S.R.L.
Frequently Asked Questions
What is adipotide used for in research?
In the published literature, adipotide is used as a research tool to study vascular targeting of white adipose tissue. It combines a peptide that homes to prohibitin on adipose-feeding blood vessels with a proapoptotic domain, letting researchers investigate what happens in model systems when that specific vasculature is ablated. It is supplied for laboratory research only and is not for human or veterinary use.
How does adipotide target fat tissue specifically?
The CKGGRAKDC portion of the molecule was identified through in vivo phage-display screening for peptides that home to white adipose tissue vasculature. Its target, prohibitin, is displayed on the endothelium of fat-feeding vessels. Once the homing peptide binds, the D(KLAKLAK)2 domain is internalised and disrupts mitochondrial membranes, so activity is concentrated at the targeted vascular bed rather than distributed broadly.
What did the primate study report?
Barnhart and colleagues (2011, Science Translational Medicine) studied adipotide in rhesus monkeys, reporting on tissue selectivity, metabolic parameters and renal markers in the model animals. This primate dataset is the most advanced preclinical reference point cited for the compound.
What is a proapoptotic peptide-drug conjugate?
It is a molecule that pairs a targeting peptide with a cell-death-inducing payload, conceptually similar to an antibody-drug conjugate. In adipotide, the targeting peptide delivers the D(KLAKLAK)2 domain to adipose endothelial cells; the payload only acts where the targeting element has bound, which is the source of the conjugate's selectivity in research models.
How should adipotide be stored?
Store the lyophilized powder at −20°C, protected from light. After reconstitution with sterile water or PBS, keep refrigerated at 2–8°C and use within roughly 14 days. Handle in line with standard peptide-handling and institutional biosafety guidelines.
For research purposes only. Not for human consumption.
Related research reading
Objective comparisons and research guides covering this compound. Reference material, for research purposes only.
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every vial label carries a code. Look it up on our Verify page: it shows what CertaPeptides publishes for that code and, for a withdrawn lot, that the lot was withdrawn and why. If yours is withdrawn, or if the code on your label finds nothing, email us that code.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland). Delivery 1–15 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with escalation to ANPC and alternative dispute resolution (SAL) available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
