Thymosin Alpha-1

About Thymosin Alpha-1

Thymosin Alpha-1 (CAS: 62304-98-7) is a naturally occurring 28-amino acid peptide first isolated from thymosin fraction 5, a preparation derived from bovine thymus tissue. It is an N-terminally acetylated peptide that plays a central role in immune system maturation and regulation. Thymosin Alpha-1 has been one of the most extensively studied thymic peptides, with research spanning several decades across immunology and infectious condition fields.

Mechanism of Action

Thymosin Alpha-1 acts as a biological response modifier, enhancing immune function through multiple pathways. It promotes the differentiation and maturation of dendritic cells, enhancing their antigen-presenting capacity. The peptide stimulates T-cell maturation from progenitor cells via upregulation of T-cell surface markers. It modulates cytokine production, shifting the balance toward Th1 responses, and activates natural killer (NK) cell cytotoxicity. Additionally, Thymosin Alpha-1 signals through Toll-like receptors (TLR-2 and TLR-9) on myeloid and plasmacytoid dendritic cells.

Published Research

• Romani, L., et al. (2007). Thymosin Alpha-1: an endogenous regulator of inflammation, immunity, and tolerance. Clinical Immunology. DOI: 10.1016/j.clim.2006.11.010
• Wu, M., et al. (2020). Thymosin Alpha-1 as an immunomodulatory agent in sepsis management. Annals of Intensive Care. DOI: 10.1186/s13613-020-00710-3

Product Specifications

• Molecular Weight: 3108.3 Da
• CAS Number: 62304-98-7
• Sequence: Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN (28-AA)
• Purity: 99.3% avg (HPLC)
• Form: Lyophilized powder
• Storage: -20°C, protected from light

View Certificate of Analysis (COA)

This product is intended for laboratory research use only. Not for human consumption. Not a compound, food, or cosmetic. CertaPeptides does not condone or encourage any off-label use.