Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
GHK-Cu
3–7 days most of the EU · 8–14 Nordics/Baltics
Standard EU from €4.99 (RO) · core EU GLS €17.99 · Nordics/Baltics €12.99–€13.99 · Same-day dispatch before 14:00 CET on weekdays · Free shipping over €200 · no customs paperwork (EU) · via EU carrier network
€200.00 away from free shipping over €200. Under that, standard EU shipping is €17.99 (GLS, most of the EU).
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GHK-Cu is a naturally occurring copper-binding tripeptide (Glycyl-L-histidyl-L-lysine copper complex) studied extensively in tissue biology and cellular remodeling research. Concentration declines with age, making it a key compound in age-related biological studies. Shipped to a ≥98% supplier batch specification; selected lots independently tested. Key research areas: Tissue remodeling and extracellular matrix pathways Collagen and decorin synthesis stimulation Gene expression modulation (over 4,000 genes identified) For research purposes only. Not for human consumption.
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €39.99 | €39.99 | -- |
| 3+ | €37.99 | €113.97 | 5% off |
| 5+Most Popular | €35.99 | €179.95 | 10% off |
| 10+ | €33.99 | €339.92 | 15% off |
Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
Recommended: PBS · stable for 21 days at 2-8°C once mixed.
When This Product May Not Suit Your Research
- ⚠If your research requires a non-metallopeptide — GHK-Cu contains a copper(II) ion integral to its structure.
- ⚠If your assay is sensitive to metal interference — the copper ion may interfere with certain spectrophotometric methods.
- ⚠If you need a peptide with extensive human clinical trial data — GHK-Cu's clinical evidence is primarily from topical applications.
Published laboratory reports are available for selected lots. Check each report for its result and stated method. For research purposes only.
View report #212150 on janoshik.com →
24h dispatch, EU-wide shipping from €4.99
Supplier batch specification on every product; independent Janoshik report on selected lots
About GHK-Cu
About GHK-Cu
GHK-Cu (CAS 49557-75-7) is a tripeptide-copper complex first isolated from human plasma by Dr. Loren Pickart in 1973. Endogenous plasma concentrations decline from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60, a reduction that correlates with diminished tissue remodeling capacity. This naturally occurring peptide has become one of the most studied compounds in regenerative biology and gene expression research.
Mechanism of Action
GHK-Cu functions as a biological signaling molecule that binds copper(II) ions with high affinity, facilitating copper delivery to enzymatic processes essential for tissue maintenance. The peptide activates TGF-beta and VEGF signaling pathways, stimulating fibroblast proliferation, collagen I/III synthesis, and glycosaminoglycan production. Gene expression studies using the Connectivity Map database have identified GHK as a modulator of over 4,000 human genes.
Published Research
- Gene expression modulation: Connectivity Map analysis identified GHK as capable of resetting the expression of 4,048 genes toward a profile associated with healthy tissue maintenance. (DOI)
- Tissue biology and collagen synthesis: Research demonstrated that GHK-Cu promoted tissue remodeling and increased collagen synthesis, antioxidant enzyme levels, and blood vessel formation. (DOI)
- Tissue remodeling: A comprehensive review detailed how GHK-Cu promotes extracellular matrix remodeling by stimulating synthesis of collagen, decorin, elastin, and glycosaminoglycans. (DOI)
Product Specifications
- Purity: ≥98% (supplier batch spec)
- Form: Lyophilized powder
- CAS: 49557-75-7
- Molecular Weight: 403.9 Da
Selected lots are independently tested by Janoshik Analytical; reports are searchable by batch code at certapeptides.com/verify →
Third-party heavy metals + purity report: Janoshik Analytical Report #136727 (GHK-Cu 50mg) — independent lead, mercury, arsenic, cadmium analysis + HPLC purity verification by a Czech laboratory.
For research purposes only. Not for human consumption.
Specification Summary
About GHK-Cu
About GHK-Cu
GHK-Cu (CAS 49557-75-7) is a tripeptide-copper complex first isolated from human plasma by Dr. Loren Pickart in 1973. Endogenous plasma concentrations decline from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60, a reduction that correlates with diminished tissue remodeling capacity. This naturally occurring peptide has become one of the most studied compounds in regenerative biology and gene expression research.
Mechanism of Action
GHK-Cu functions as a biological signaling molecule that binds copper(II) ions with high affinity, facilitating copper delivery to enzymatic processes essential for tissue maintenance. The peptide activates TGF-beta and VEGF signaling pathways, stimulating fibroblast proliferation, collagen I/III synthesis, and glycosaminoglycan production. Gene expression studies using the Connectivity Map database have identified GHK as a modulator of over 4,000 human genes.
Published Research
- Gene expression modulation: Connectivity Map analysis identified GHK as capable of resetting the expression of 4,048 genes toward a profile associated with healthy tissue maintenance. (DOI)
- Tissue biology and collagen synthesis: Research demonstrated that GHK-Cu promoted tissue remodeling and increased collagen synthesis, antioxidant enzyme levels, and blood vessel formation. (DOI)
- Tissue remodeling: A comprehensive review detailed how GHK-Cu promotes extracellular matrix remodeling by stimulating synthesis of collagen, decorin, elastin, and glycosaminoglycans. (DOI)
Product Specifications
- Purity: ≥98% (supplier batch spec)
- Form: Lyophilized powder
- CAS: 49557-75-7
- Molecular Weight: 403.9 Da
Selected lots are independently tested by Janoshik Analytical; reports are searchable by batch code at certapeptides.com/verify →
Third-party heavy metals + purity report: Janoshik Analytical Report #136727 (GHK-Cu 50mg) — independent lead, mercury, arsenic, cadmium analysis + HPLC purity verification by a Czech laboratory.
For research purposes only. Not for human consumption.
What research shows
Selected peer-reviewed studies from the published literature. Each describes laboratory or preclinical findings and is attributed to the cited study, not to this product. For research use only — not medical guidance.
Skin regeneration signalling
In in-vitro research, the GHK peptide (copper tripeptide-1) has been characterized as a modulator of multiple cellular pathways relevant to skin regeneration.
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International (2015). PMID: 26236730Wound healing
In an irradiated rat model, topical copper tripeptide (GHK-Cu) complex was studied for its effects on wound healing.
Effects of topical copper tripeptide complex on wound healing in an irradiated rat model. Otolaryngology–Head and Neck Surgery (2013). PMID: 23744835Anti-inflammatory activity
In a mouse model of lipopolysaccharide-induced acute lung injury, the GHK-Cu tripeptide complex was associated with reduced injury markers in laboratory research.
The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget (2016). PMID: 27517151Citations are provided for research reference. CertaPeptides (CERTALAB S.R.L.) is a reseller, not a manufacturer, and makes no medical, therapeutic, or efficacy claims. Products are for laboratory research use only and are not for human or animal consumption.
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland, Iceland, Serbia). Delivery 1–15 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
Frequently Asked
Related Research Articles
Researchers also explore related blends
Researchers studying GHK-Cu also explore the fixed-ratio multi-peptide blends your supplier offers, each supplied as a single vial. Provided for laboratory research use only.
Glow Blend (BPC-157 + GHK-Cu + TB-500) 70mg
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Klow Blend (BPC-157 + GHK-Cu + TB-500 + KPV) 80mg
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