AOD-9604

About AOD-9604

What is AOD-9604?
Take human growth hormone. Cut it down to just amino acids 177-191. Stick a tyrosine on the N-terminus. What you get is a fragment that retained HGH lipid metabolism signaling activity and lost everything else — no growth effects, no IGF-1 elevation, no glucose impairment. Monash University in Australia spent years characterizing this, and the selectivity is genuinely interesting.

CAS: 221231-10-3. The idea that you can surgically extract one function from a large hormone by identifying the right fragment has broader implications for peptide pharmacology.

Mechanism of Action

What it does and does not do
Does: modulate lipid metabolism signaling via beta-3 adrenergic pathways in adipose tissue. Modulate lipogenesis pathways (de novo lipid synthesis signaling). Influence fatty acid oxidation pathway signaling.

Does not: bind the growth hormone receptor. Stimulate IGF-1. Promote tissue growth. Impair glucose tolerance. That last point is important — full-length HGH tends to cause insulin resistance at higher doses. AOD-9604 does not.

Research Overview

There is also emerging cartilage data. Chondrocyte proliferation effects have been reported, which is an unexpected finding for a lipid metabolism signaling fragment.

Research context
Adipose tissue signaling research. Body composition endpoint research without GH axis confounding. Oral bioavailability studies (one of few peptides with published oral delivery data). Cartilage and osteoarthritis models. Comparative work against HGH Fragment 176-191 (the unmodified native sequence).

Specs

Molecular weight1,817.1 Da
CAS221231-10-3
Purity99.3% avg by HPLC
FormLyophilized powder
Sizes2mg, 5mg

Product Specifications

• Purity: 99.3% avg (HPLC verified)
• Form: Lyophilized powder
• SKU: CP-AOD

Certificate of Analysis available for every batch. View COAs →

For research purposes only. Not for human consumption.