Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
SNAP-8 10mg
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SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that mimics the N-terminal domain of SNAP-25. Investigated for modulating neuromuscular junction activity. Supplied as lyophilized powder; class-level specification ≥98%; selected lots are independently tested. For research purposes only. Not for human consumption.
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €25.49 | €25.49 | -- |
| 3+ | €24.22 | €72.65 | 5% off |
| 5+Most Popular | €22.94 | €114.71 | 10% off |
| 10+ | €21.67 | €216.67 | 15% off |
Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Published laboratory reports are available for selected lots. Check each report for its result and stated method. For research purposes only.
View report #233652 on janoshik.com →
Dispatched within 1–2 business days, shipping from €4.99 in Romania, from €12.99 across the rest of Europe
Class-level specification on record; independent Janoshik report on selected lots
About SNAP-8 10mg
SNAP-8 (Acetyl Glutamyl Heptapeptide-3) is a synthetic octapeptide that acts as a competitive antagonist of SNAP-25, one of the SNARE complex proteins involved in vesicle fusion at neuromuscular junctions. The mechanism mirrors what botulinum toxin does at a structural level -- disrupting the SNARE machinery that triggers acetylcholine release -- but achieves this through peptide competition rather than enzymatic cleavage. SNAP-25 is a 206-residue membrane-associated protein; SNAP-8 mimics a small segment of it to compete for the assembly of the fusion complex.
Research Applications
The primary research interest in SNAP-8 is mechanistic: it provides a way to study neuromuscular transmission and vesicle exocytosis without the safety complications of using the botulinum toxin itself. Because it acts through competitive inhibition rather than irreversible protease activity, its effects are concentration-dependent and reversible within the experimental timescale -- which gives researchers more control over dose-response characterization.
Dermatological research has also used SNAP-8 as a model compound for studying topical peptide delivery and its effects on facial muscle contraction patterns. Whether peptide applied to skin surface can reach neuromuscular junctions in sufficient concentration to produce measurable physiological effects is genuinely debated. Some ex vivo skin models and some small experimental measurements have shown signals, others have not. The question of penetration depth relative to target depth remains unsettled. SNAP-8 is a useful tool compound for investigating this penetration question directly.
Specifications
| Parameter | Value |
|---|---|
| Active compound | SNAP-8 (Acetyl Glutamyl Heptapeptide-3) |
| Quantity | 10mg lyophilized powder |
| Purity | ≥98% (class-level specification) |
| Molecular weight | 1075.2 Da |
| Target protein | SNAP-25 (synaptosomal-associated protein 25) |
| Mechanism | SNARE complex competitive inhibition |
| Form | Lyophilized powder |
| Independent testing | Selected lots tested by Janoshik Analytical; searchable at certapeptides.com/verify |
Storage
Store at -20°C, away from light and moisture. Reconstitute in sterile water at the concentration needed for your assay. Reconstituted solution is stable at 4°C for up to 14 days. Not compatible with strong reducing agents, which can alter the acetyl group. For vesicle fusion assays, prepare fresh dilutions immediately before use.
How does SNAP-8 compare to botulinum toxin as a research tool?
Botulinum toxin cleaves SNARE proteins irreversibly through enzymatic activity, which makes dose-response experiments difficult once you are past the threshold. It also requires strict biohazard handling. SNAP-8 offers a reversible, concentration-dependent handle on the same pathway with far simpler logistics. The trade-off is potency -- botulinum toxin is active at subnanomolar concentrations while SNAP-8 is effective in the micromolar range. For mechanistic studies of SNARE assembly kinetics, SNAP-8 is often the more tractable choice.
What in vitro models are appropriate for SNAP-8 research?
Liposome fusion assays using fluorescent lipid mixing are the standard for quantifying SNARE-mediated membrane fusion in a minimal reconstituted system. Neuronal cell cultures (PC12 cells or primary motor neurons) with catecholamine release readouts offer a more physiologically relevant model. Electrophysiological assays in cultured neuromuscular preparations allow direct measurement of miniature end-plate potential frequency changes. Each model has different artifacts to control for, so converging evidence from at least two systems strengthens mechanistic conclusions.
SNAP-8 is supplied for laboratory research use only. Not for human consumption. For research purposes only.
Specification Summary
About SNAP-8 10mg
SNAP-8 (Acetyl Glutamyl Heptapeptide-3) is a synthetic octapeptide that acts as a competitive antagonist of SNAP-25, one of the SNARE complex proteins involved in vesicle fusion at neuromuscular junctions. The mechanism mirrors what botulinum toxin does at a structural level -- disrupting the SNARE machinery that triggers acetylcholine release -- but achieves this through peptide competition rather than enzymatic cleavage. SNAP-25 is a 206-residue membrane-associated protein; SNAP-8 mimics a small segment of it to compete for the assembly of the fusion complex.
Research Applications
The primary research interest in SNAP-8 is mechanistic: it provides a way to study neuromuscular transmission and vesicle exocytosis without the safety complications of using the botulinum toxin itself. Because it acts through competitive inhibition rather than irreversible protease activity, its effects are concentration-dependent and reversible within the experimental timescale -- which gives researchers more control over dose-response characterization.
Dermatological research has also used SNAP-8 as a model compound for studying topical peptide delivery and its effects on facial muscle contraction patterns. Whether peptide applied to skin surface can reach neuromuscular junctions in sufficient concentration to produce measurable physiological effects is genuinely debated. Some ex vivo skin models and some small experimental measurements have shown signals, others have not. The question of penetration depth relative to target depth remains unsettled. SNAP-8 is a useful tool compound for investigating this penetration question directly.
Specifications
| Parameter | Value |
|---|---|
| Active compound | SNAP-8 (Acetyl Glutamyl Heptapeptide-3) |
| Quantity | 10mg lyophilized powder |
| Purity | ≥98% (class-level specification) |
| Molecular weight | 1075.2 Da |
| Target protein | SNAP-25 (synaptosomal-associated protein 25) |
| Mechanism | SNARE complex competitive inhibition |
| Form | Lyophilized powder |
| Independent testing | Selected lots tested by Janoshik Analytical; searchable at certapeptides.com/verify |
Storage
Store at -20°C, away from light and moisture. Reconstitute in sterile water at the concentration needed for your assay. Reconstituted solution is stable at 4°C for up to 14 days. Not compatible with strong reducing agents, which can alter the acetyl group. For vesicle fusion assays, prepare fresh dilutions immediately before use.
How does SNAP-8 compare to botulinum toxin as a research tool?
Botulinum toxin cleaves SNARE proteins irreversibly through enzymatic activity, which makes dose-response experiments difficult once you are past the threshold. It also requires strict biohazard handling. SNAP-8 offers a reversible, concentration-dependent handle on the same pathway with far simpler logistics. The trade-off is potency -- botulinum toxin is active at subnanomolar concentrations while SNAP-8 is effective in the micromolar range. For mechanistic studies of SNARE assembly kinetics, SNAP-8 is often the more tractable choice.
What in vitro models are appropriate for SNAP-8 research?
Liposome fusion assays using fluorescent lipid mixing are the standard for quantifying SNARE-mediated membrane fusion in a minimal reconstituted system. Neuronal cell cultures (PC12 cells or primary motor neurons) with catecholamine release readouts offer a more physiologically relevant model. Electrophysiological assays in cultured neuromuscular preparations allow direct measurement of miniature end-plate potential frequency changes. Each model has different artifacts to control for, so converging evidence from at least two systems strengthens mechanistic conclusions.
SNAP-8 is supplied for laboratory research use only. Not for human consumption. For research purposes only.
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every vial label carries a code. Look it up on our Verify page: it shows what CertaPeptides publishes for that code and, for a withdrawn lot, that the lot was withdrawn and why. If yours is withdrawn, or if the code on your label finds nothing, email us that code.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland). Delivery 1–15 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with escalation to ANPC and alternative dispute resolution (SAL) available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
