GW-501516/Cardarine 10mg

GW-501516, commonly called Cardarine, is frequently grouped with SARMs in research catalogs, but it doesn't bind to the androgen receptor. It's a PPARdelta agonist -- peroxisome proliferator-activated receptor delta -- which puts it in a different class of nuclear receptor pharmacology entirely. The mechanism is worth understanding clearly before interpreting the research.

PPARdelta is a nuclear receptor involved in regulating fatty acid oxidation, glucose metabolism, and mitochondrial activity, particularly in skeletal muscle and adipose tissue. Activating it in rodent models produces changes in fuel utilization -- increased fat burning, preserved glycogen, enhanced running endurance -- which explains why it attracted attention in metabolic and athletic performance research. Some studies in genetically modified mice showed dramatic endurance improvements, which generated significant interest.

The reason GW-501516's development was halted at GlaxoSmithKline is worth noting: accelerated tumor development was observed in multiple organ systems in rodent carcinogenicity studies, which caused GSK to terminate the program. The mechanism appears to involve PPARdelta's role in promoting cell survival and proliferation pathways. This is not a minor finding, and researchers working with this compound should be familiar with that literature.

Research Applications

GW-501516 is used in metabolic research -- specifically for studying fatty acid oxidation, PPARdelta receptor pharmacology, skeletal muscle fuel utilization, and mitochondrial biogenesis. It's also used as a tool compound to understand PPARdelta's role in various biological contexts.

Specifications

Storage

Store at -20°C in the original sealed vial. Stable for 24+ months. Minimize light and moisture exposure during handling.

GW-501516 is supplied for laboratory research use only. Not approved for human use. Handle in compliance with institutional biosafety guidelines.