RAD140 10mg

RAD140, or Testolone, has attracted significant research attention for two reasons that don't always get discussed together: it's among the most potent AR binders in the SARM class, and it appears to have activity in neural tissue that's separate from its anabolic effects. That combination makes it useful for studying androgen receptor biology beyond muscle physiology.

In terms of binding affinity, RAD140 competes favorably with testosterone at the androgen receptor -- some assays show it matching or exceeding testosterone's affinity while maintaining tissue selectivity that distinguishes SARMs from classical androgens. The selective part is what differentiates it from testosterone, which activates AR broadly across tissues including the prostate.

The neuroprotective angle comes from the fact that androgen receptors are expressed in neurons, and AR activation in neural tissue produces effects distinct from hormonal signaling elsewhere. Some studies have looked at RAD140's effects on amyloid-beta toxicity and neurotrophic signaling, finding evidence of protective activity in cell and rodent models. This research is earlier-stage than the anabolic side but has expanded the compound's relevance beyond sports science contexts.

Research Applications

RAD140 appears in research on anabolic/catabolic balance, muscle and bone tissue biology, androgen receptor pharmacology, and neuroprotection. The divergence between neural and peripheral AR effects is itself a research question -- understanding how the same receptor produces different downstream outcomes in different tissue types.

Specifications

Storage

Store at -20°C in the original sealed vial. Stable under proper storage for 24+ months. RAD140 is light-sensitive -- minimize exposure during preparation. For extended use, consider aliquoting to avoid repeated freeze-thaw cycles.

RAD140 is supplied for laboratory research use only. Not approved for human use. Handle in compliance with institutional biosafety guidelines.