SR9009 10mg

SR9009 sits in an unusual corner of receptor pharmacology. It's classified alongside SARMs in most research catalogs, but it's actually a Rev-ErbA agonist -- binding to circadian clock proteins rather than androgen receptors. The distinction matters for understanding what you're studying and why the rodent data looks the way it does.

Rev-ErbA proteins (alpha and beta isoforms) are nuclear receptors that help regulate the body's circadian oscillator. They influence gene expression tied to metabolism, mitochondrial biogenesis, and inflammatory signaling. SR9009 activates both isoforms, which in cell and animal models produces effects that look superficially similar to endurance training -- increased mitochondrial density, enhanced fatty acid oxidation, changes in skeletal muscle gene expression. Some researchers describe this mechanism as "exercise mimetic," though that phrase probably overstates what the data shows.

The bioavailability issue is worth knowing upfront: early rodent studies typically used intraperitoneal injection rather than oral dosing, partly because SR9009 has relatively poor oral bioavailability in rat models. Whether this translates to the same constraint in other species is unclear. It's a meaningful caveat when interpreting the preclinical literature.

Research Applications

Most published SR9009 research has focused on metabolic parameters -- lipid profiles, glucose handling, fat mass in diet-induced obesity models -- and on endurance capacity in rodents. There's also some work examining circadian rhythm disruption models, where Rev-ErbA agonism might help re-entrain disrupted biological clocks. The neuroprotective angle has been explored too, given Rev-ErbA's presence in neural tissue, though this is earlier-stage research.

Specifications

Storage

Store at -20°C in the original sealed vial. SR9009 is light-sensitive -- minimize exposure during handling. Once dissolved, use promptly or aliquot to avoid repeated freeze-thaw cycles. DMSO solutions are commonly used in research protocols.

SR9009 is supplied for laboratory research use only. Not approved for human use. Handle in compliance with institutional biosafety guidelines.