LGD-4033/Ligandrol 10mg

LGD-4033 (Ligandrol) is a non-steroidal selective androgen receptor modulator from Ligand Pharmaceuticals — one of the most potent SARMs in terms of anabolic activity per dose and one of the better-characterized from a human pharmacokinetics standpoint. It progressed through Phase I and Phase II clinical trials, producing the dose-response data and safety profile that subsequent muscle wasting research relies on. CAS: 1165910-22-4. MW 338.3 Da. Oral capsule.

What "Selective" Actually Means Here

Testosterone activates androgen receptors everywhere: muscle, bone, prostate, sebaceous glands, hair follicles, the hypothalamic-pituitary axis. SARMs like LGD-4033 aim to activate AR in the anabolic tissues while reducing signaling in androgenic tissues. The selectivity is real but partial. LGD-4033 suppresses LH and FSH in a dose-dependent manner — the HPG axis detects AR activation and reduces gonadotropin output — which is the main reason it does not fully decouple anabolic from hormonal effects.

Understanding that dose-response relationship is one of the primary research uses for this compound. In Phase I, the lean mass effects were clear; so was the dose-dependent HPG suppression. LGD-4033 serves as the high-potency SARM reference compound in comparative pharmacology work alongside lower-potency compounds like Ostarine.

Specifications

Storage: Room temperature, away from moisture and direct light.

Quality: HPLC purity analysis, mass spec identity confirmation, endotoxin testing on every batch. COA ships with every order. EU-based QC under CERTALAB S.R.L.

For research purposes only. Not for human consumption.