SLU-PP-332

SLU-PP-332 is a small molecule ERRalpha/ERRgamma agonist developed at Saint Louis University as a pharmacological tool for the estrogen-related receptor (ERR) pathway. ERRalpha and ERRgamma are orphan nuclear receptors -- so called because they lack identified endogenous ligands -- that regulate mitochondrial biogenesis, oxidative phosphorylation, and fatty acid metabolism. Before SLU-PP-332, selective ERR agonists were limited, which constrained the ability to study ERR pharmacology without genetic manipulation.

This product is supplied as pre-dosed oral capsules. SLU-PP-332's small molecule structure (MW 490.6 Da) gives it oral bioavailability, distinguishing it from peptide exercise mimetics that require injection, and the capsule format provides standardized units for chronic oral-administration protocols in research models without weighing powder for each unit.

The exercise mimetic framing comes from what ERR activation is studied to do in research models: it is associated with many of the same transcriptional programs as endurance exercise -- PGC-1alpha-dependent mitochondrial biogenesis, increased expression of oxidative enzymes, and fiber type shifts toward slow-twitch oxidative phenotypes. This pathway is one of several investigated for exercise mimetic pharmacology alongside AMPK activators (like AICAR) and Rev-Erbalpha agonists (like SR9009).

Research Applications

SLU-PP-332 is used in research on ERR nuclear receptor pharmacology, mitochondrial biogenesis and dynamics, exercise physiology and metabolic adaptation, obesity and cardiovascular disease models, and comparative exercise mimetic studies alongside AMPK and Rev-Erb pathway compounds. The capsule format is particularly suited to chronic oral dosing studies in animal models.

Specifications

Storage

Store the capsules at room temperature in a dry place, protected from moisture and light. SLU-PP-332 is a small molecule and does not require cold storage for short-term research use.

SLU-PP-332 capsules are supplied for laboratory research use only. Not for human or veterinary use. Handle in compliance with institutional biosafety guidelines.