Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
≥98% PurityIn-House HPLC & MS Tested
Growth FactorsSKU: CP-TB500
Oral TB-500 500mcg
≥99% PurityHPLC & MS verified
€300.99Out of Stock
Delivers to EU in 7-10 business days
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Research-grade Oral TB-500. 99.3% avg purity, HPLC & MS verified. Oral tablets in sealed bottle. For laboratory research use only. Not for human consumption.
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Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Purity HPLC
99.3% average HPLC purity, verified by independent third-party testing
Third-Party Tested
Janoshik report published when available
Fast Shipping
24h dispatch, EU-wide shipping from €4.99
Third-Party Tested
Independent lab verification for every batch
Last reviewed: 2026-04-24
About Oral TB-500 500mcg
Oral TB-500 is a capsule formulation of the TB-500 peptide -- the 17-amino acid fragment of thymosin beta-4 that contains the actin-binding LKKTET motif responsible for most of thymosin beta-4's biological activity. TB-500 regulates actin polymerization, promotes cell migration, and has documented anti-inflammatory and tissue repair properties across multiple preclinical models.
The research question with oral TB-500 is pharmacological: does encapsulated TB-500 survive enough GI transit to produce local or systemic effects? TB-500 does not have BPC-157's documented gastric acid stability, so this is a genuine mechanistic unknown. Encapsulation can protect peptides from acid and enzymatic degradation to varying degrees depending on formulation. For researchers interested in oral peptide delivery strategies, TB-500 is a useful model compound -- its well-characterized actin-binding activity means that if any biological signal is detected after oral dosing, the source compound is known and the delivery pathway can be investigated. Each capsule provides 500mcg.
The TB-500 peptide has been studied for fibroblast proliferation in cited models, cardiac tissue repair after ischemia, corneal healing, and anti-inflammatory effects. The LKKTET actin-binding sequence appears to be the minimal active unit for most of thymosin beta-4's biological activities, which is why this fragment rather than the full protein is used in most research.
Research Applications
Oral TB-500 is relevant to research on oral peptide delivery pharmacology, actin dynamics and cell migration biology, tissue remodeling mechanisms, and the question of whether encapsulation strategies can enable oral bioavailability for peptides that lack native GI stability.
Specifications
| Parameter | Value |
|---|---|
| Active Ingredient | TB-500 (Thymosin Beta-4 fragment, LKKTET domain) |
| Dose per Capsule | 500mcg |
| Purity | 99.3% avg HPLC (active ingredient) |
| Format | Oral capsule, lyophilized fill |
| Storage | Room temperature or 2-8°C for extended stability |
Storage
Store at room temperature in a cool, dry place; refrigerate at 2-8°C for extended stability. Capsule form prevents immediate hydrolysis but long-term storage at elevated temperatures may reduce peptide integrity. Keep dry and away from heat.
What is TB-500 and what does it do?
TB-500 is the 17-amino acid fragment of thymosin beta-4 containing the LKKTET actin-binding motif. Thymosin beta-4 is a ubiquitous G-actin sequestering protein that regulates the pool of actin available for polymerization, affecting cell motility, migration, and cytoskeletal dynamics. TB-500's biological activities include promoting cell migration and proliferation, reducing inflammatory cytokine expression, promoting angiogenesis, and supporting tissue repair. The LKKTET sequence appears sufficient for most of thymosin beta-4's activity despite being a small fragment of the full protein.
Why is oral delivery uncertain for TB-500?
Unlike BPC-157, TB-500 does not have documented stability in gastric acid conditions. Most peptides are degraded by proteases in the stomach and small intestine before they can be absorbed. Capsule encapsulation provides some protection but the extent of protection depends on formulation specifics. This makes oral TB-500 a research tool for studying oral peptide delivery rather than a compound with assumed oral bioavailability -- the delivery question is itself part of what researchers are investigating.
What are the main research contexts for TB-500?
TB-500 has been studied in fibroblast proliferation in cited models models (skin, tendon, muscle), cardiac repair after ischemia, corneal healing, and inflammatory models. In most published preclinical research, it was administered via injection, which ensures known systemic exposure. The oral format shifts the research focus to include delivery mechanism questions alongside the established biology -- whether there is detectable activity via the oral route and what dose-response looks like in that context.
Oral TB-500 is supplied for laboratory research use only. Not approved for human use. Handle in compliance with institutional biosafety guidelines.
Specification Summary
Purity99.3% avg
FormLyophilized Powder
Storage-20\u00B0C
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Every batch is independently verified by Janoshik Analytical (100,000+ verifications/month), Eurofins Scientific, and Analytical Sciences International. We publish every Certificate of Analysis.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI RO54451735, VAT-registered. SameDay for Romania, FanCourier for Central/Eastern EU, TCE Worldwide for the rest. 3–7 business days EU-wide.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
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