Dihexa 20mg

About Dihexa 20mg

What is Dihexa?
Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) is a synthetic hexapeptide-derived angiotensin IV analog that was developed at Washington State University. Its mechanism is unusual in the nootropic research space: rather than targeting dopamine, serotonin, acetylcholine, or even the classical neurotrophic receptors like TrkB, Dihexa potentiates signaling through the hepatocyte growth factor (HGF) / c-Met receptor pathway. HGF/c-Met was known primarily as a growth and survival factor in peripheral tissues and tumor biology; research from the Bhargava and Bhattacharya labs at WSU identified that this pathway also drives synaptogenesis — the formation of new synaptic connections — in the hippocampus.

The potency figure that gets cited is striking: the original preclinical papers reported Dihexa to be approximately 10 million times more potent than BDNF at promoting synaptic connectivity in hippocampal cell assays. That claim deserves some context — the comparison isn't straightforward because BDNF and Dihexa act through entirely different receptor systems. But the functional synaptogenesis data in cognitive models (including scopolamine-impaired spatial memory tests in rodents) is notable. At 20mg the compound has enough quantity for extended in vitro studies or multiple animal experiments. The HGF/c-Met pathway in CNS remains substantially undercharacterized relative to BDNF/NGF, making Dihexa a useful tool for researchers interested in this space.

Mechanism of Action

Specifications

Molecular weight~600 Da
StructureAngiotensin IV analog (hexapeptide-derived)
MechanismHGF/c-Met pathway potentiation
Presentation20mg lyophilized
Purity≥98% HPLC
CAS1401708-83-5

FAQ

What is the HGF/c-Met pathway and why is it relevant to the CNS?

HGF (hepatocyte growth factor) and its receptor c-Met are widely known in oncology for their roles in cancer cell invasion and survival. In the CNS, the HGF/c-Met signaling axis has more recently been recognized as a regulator of neuronal survival, axon growth, and synaptic connectivity — particularly in the hippocampus. c-Met is expressed on hippocampal neurons, and HGF/c-Met signaling promotes synaptogenesis and dendritic spine formation through downstream activation of PI3K/AKT and MAPK/ERK pathways. Dihexa was identified by screening for compounds that could potentiate this pathway with high potency, which the WSU group achieved by starting from the angiotensin IV/AT4 receptor framework.

Research Overview

Storage
Store at -20°C. Dihexa has lipophilic properties (the hexanoic acid modification) that may affect solubility in pure aqueous solutions — DMSO stock solutions are often used, diluted into buffer for working concentrations. Store DMSO stocks at -20°C; aqueous solutions at 4°C for short-term.

Quality
HPLC purity analysis, mass spec identity confirmation, endotoxin testing on every batch. COA ships with every order. EU-based QC under CERTALAB S.R.L.

For research purposes only. Not for human consumption.

Product Specifications

• Purity: 99.3% avg (HPLC verified)
• Form: Lyophilized powder
• SKU: CP-DHA20

Certificate of Analysis available for every batch. View COAs →

For research purposes only. Not for human consumption.