Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
5-amino-1mq
Free shipping on orders over €200
- If a product doesn't match the specification on its published COA, contact us with your batch number: we investigate against the lot's report and replace any product that fails it, at no cost to you.
- Contact us within 48 hours of delivery with photos of the outer box, inner packing, and any affected vials with labels legible. Confirmed transit damage is replaced at no cost to you.
3–7 days most of the EU · 10–14 Nordics/Baltics
Standard EU from €4.99 (RO) · core EU GLS €17.99 · Nordics/Baltics €12.99–€15.99 · Dispatched within 1–2 business days · Free shipping over €200.00 · no customs paperwork (EU) · via EU carrier network
€200.00 away from free shipping over €200.00. Under that, standard EU shipping is €17.99 (GLS, most of the EU).
How Paysera and SEPA work
- Pay: send a manual SEPA transfer using the IBAN we email you, or, where checkout offers it for your address, approve a SEPA transfer in your own bank via Paysera's hosted page.
- We confirm — Paysera notifies us instantly, or we match a manual transfer when it arrives (usually 1 business day).
- We dispatch — confirmed orders typically ship within 1–2 business days.
Card payments are not currently offered. There is no card processor on this checkout.
Research-grade 5-amino-1mq. Class-level specification ≥98%; selected lots independently tested. Lyophilized powder in sealed glass vial. For laboratory research use only. Not for human consumption.
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €29.99 | €29.99 | -- |
| 3+ | €28.49 | €85.47 | 5% off |
| 5+Most Popular | €26.99 | €134.95 | 10% off |
| 10+ | €25.49 | €254.92 | 15% off |
Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Due to legal and regulatory requirements, this product cannot be shipped to: Croatia, Italy, Lithuania, and Slovenia.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Published laboratory reports are available for selected lots. Check each report for its result and stated method. For research purposes only.
View report #233642 on janoshik.com →
Dispatched within 1–2 business days, shipping from €4.99 in Romania, from €12.99 across the rest of Europe
Class-level specification on record; independent Janoshik report on selected lots
About 5-amino-1mq
Most metabolic research targets hormone receptors. 5-Amino-1MQ targets an enzyme. Specifically, it inhibits NNMT — nicotinamide N-methyltransferase — a cytoplasmic enzyme that methylates nicotinamide using S-adenosylmethionine as the methyl donor. That reaction consumes two things simultaneously: nicotinamide (a NAD+ precursor) and SAM (the universal methyl donor for DNA and histone methylation). Inhibit NNMT and both accumulate. CAS: 42464-98-2. MW 231.3 Da. Cell-permeable small molecule.
Why This Target
NNMT expression is elevated in obese white adipose tissue. Preclinical work — including research from the Brenner lab — suggests NNMT inhibition shifts adipocyte metabolism toward increased energy expenditure. Not by directly stimulating thermogenesis, but by altering the metabolic program of the cell. The NAD+ increase feeds into SIRT1, which downstream affects mitochondrial biogenesis and fatty acid oxidation. The SAM conservation effect also alters methylation-dependent gene regulation.
The honest answer is that the full downstream biology of NNMT inhibition isn't completely characterized. That's part of what makes it interesting — it sits at the intersection of NAD+ metabolism and epigenetic regulation, two active enough fields that the implications keep expanding. For researchers working on adipose tissue metabolism, NAD+ biology, or the epigenetics of metabolic disease, this is a tool that reaches all three at once.
Specifications
| Molecular Weight | 231.3 Da |
|---|---|
| CAS | 42464-98-2 |
| Purity | ≥98% (class-level specification) |
| Form | Lyophilized powder / Capsule |
| Sizes | 5mg, 10mg, 50mg (60 capsules) |
Storage: Room temperature, away from moisture and direct light. Lyophilized form: −20°C.
Quality: Class-level specification ≥98%; selected lots are independently tested by Janoshik Analytical, searchable by batch or report code at certapeptides.com/verify. Sold and shipped from the EU by CERTALAB S.R.L.
Frequently Asked Questions
What is NNMT and why inhibit it?
NNMT (nicotinamide N-methyltransferase) is an enzyme that methylates nicotinamide, consuming both a NAD+ precursor and S-adenosylmethionine (the main cellular methyl donor). When NNMT is overactive — as in obese adipose tissue — it depletes the cell of nicotinamide and SAM. Inhibiting NNMT lets both accumulate, which feeds into NAD+-dependent pathways (sirtuins, PARP, etc.) and SAM-dependent methylation. The net effect in preclinical models is a shift in adipocyte metabolism toward greater energy expenditure.
What research has been done on 5-amino-1MQ?
Most published work is preclinical. Key papers from the Brenner and Bhatt labs at Cornell and elsewhere demonstrated NNMT inhibition reduces adiposity and improves metabolic markers in mouse models without caloric restriction. The mechanism is still being characterized — the NAD+ and SAM effects have independent downstream consequences that are actively being mapped. Human clinical data doesn't yet exist.
For research purposes only. Not for human consumption.
Specification Summary
About 5-amino-1mq
Most metabolic research targets hormone receptors. 5-Amino-1MQ targets an enzyme. Specifically, it inhibits NNMT — nicotinamide N-methyltransferase — a cytoplasmic enzyme that methylates nicotinamide using S-adenosylmethionine as the methyl donor. That reaction consumes two things simultaneously: nicotinamide (a NAD+ precursor) and SAM (the universal methyl donor for DNA and histone methylation). Inhibit NNMT and both accumulate. CAS: 42464-98-2. MW 231.3 Da. Cell-permeable small molecule.
Why This Target
NNMT expression is elevated in obese white adipose tissue. Preclinical work — including research from the Brenner lab — suggests NNMT inhibition shifts adipocyte metabolism toward increased energy expenditure. Not by directly stimulating thermogenesis, but by altering the metabolic program of the cell. The NAD+ increase feeds into SIRT1, which downstream affects mitochondrial biogenesis and fatty acid oxidation. The SAM conservation effect also alters methylation-dependent gene regulation.
The honest answer is that the full downstream biology of NNMT inhibition isn't completely characterized. That's part of what makes it interesting — it sits at the intersection of NAD+ metabolism and epigenetic regulation, two active enough fields that the implications keep expanding. For researchers working on adipose tissue metabolism, NAD+ biology, or the epigenetics of metabolic disease, this is a tool that reaches all three at once.
Specifications
| Molecular Weight | 231.3 Da |
|---|---|
| CAS | 42464-98-2 |
| Purity | ≥98% (class-level specification) |
| Form | Lyophilized powder / Capsule |
| Sizes | 5mg, 10mg, 50mg (60 capsules) |
Storage: Room temperature, away from moisture and direct light. Lyophilized form: −20°C.
Quality: Class-level specification ≥98%; selected lots are independently tested by Janoshik Analytical, searchable by batch or report code at certapeptides.com/verify. Sold and shipped from the EU by CERTALAB S.R.L.
Frequently Asked Questions
What is NNMT and why inhibit it?
NNMT (nicotinamide N-methyltransferase) is an enzyme that methylates nicotinamide, consuming both a NAD+ precursor and S-adenosylmethionine (the main cellular methyl donor). When NNMT is overactive — as in obese adipose tissue — it depletes the cell of nicotinamide and SAM. Inhibiting NNMT lets both accumulate, which feeds into NAD+-dependent pathways (sirtuins, PARP, etc.) and SAM-dependent methylation. The net effect in preclinical models is a shift in adipocyte metabolism toward greater energy expenditure.
What research has been done on 5-amino-1MQ?
Most published work is preclinical. Key papers from the Brenner and Bhatt labs at Cornell and elsewhere demonstrated NNMT inhibition reduces adiposity and improves metabolic markers in mouse models without caloric restriction. The mechanism is still being characterized — the NAD+ and SAM effects have independent downstream consequences that are actively being mapped. Human clinical data doesn't yet exist.
For research purposes only. Not for human consumption.
Related research reading
Objective comparisons and research guides covering this compound. Reference material for research use only.
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every vial label carries a code. Look it up on our Verify page: it shows what CertaPeptides publishes for that code and, for a withdrawn lot, that the lot was withdrawn and why. If yours is withdrawn, or if the code on your label finds nothing, email us that code.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland). Delivery 1–15 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with escalation to ANPC and alternative dispute resolution (SAL) available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
