GHRP-2 Acetate

GHRP-2 (Pralmorelin) is a synthetic hexapeptide GHS-R1a agonist — among the first-generation GHRPs, it delivers the strongest GH release per unit dose. That potency is the reason it became the standard positive control in GH release assays. CAS: 158861-67-7. MW 817.9 Da. Decades of published data across multiple species and administration routes. If you need a well-characterized GHSR agonist with the widest published dataset, GHRP-2 is it.

Potency vs. Selectivity

GHRP-2 produces larger GH pulses than ipamorelin, but with less receptor selectivity. At the pituitary, it activates both GHS-R1a (GH release) and ACTH pathways, elevating cortisol. Prolactin rises mildly at higher doses. These off-target hormonal effects are the reason ipamorelin displaced GHRP-2 in protocols where clean GH release without cortisol confounding is required.

The off-targets are not always a problem. If the research question involves GHS-R pharmacology across pituitary cell types, ACTH axis cross-talk, or full characterization of ghrelin receptor signaling, those effects are part of the data. GHRP-2 is more useful than ipamorelin for those questions precisely because it is less selective. Comparison with GHRP-6 is also worth noting: GHRP-2 gives more GH per unit dose; GHRP-6 produces stronger appetite stimulation through hypothalamic GHS-R activation.

Specifications

Storage: Lyophilized: −20°C, away from light. Once reconstituted: 2–8°C, use within 4 weeks.

Quality: HPLC purity analysis, mass spec identity confirmation, endotoxin testing on every batch. COA ships with every order. EU-based QC under CERTALAB S.R.L.

For research purposes only. Not for human consumption.