Cortagen 20mg

Cortagen is a tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulatory series, targeting the cerebral cortex and nervous system tissue. The name suggests adrenal cortex, but the primary research focus is neurological — cortical neuron homeostasis, age-related cognitive decline, and CNS tissue bioregulation. The adrenal overlap is secondary.

CNS-targeting bioregulators raise a specific practical question: blood-brain barrier crossing. Short peptides (2-4 amino acids) have more favorable BBB passage characteristics than larger peptides — the reduced molecular size and high polarity-flexibility ratio of tetrapeptides is part of the theoretical rationale for this class at CNS targets. Whether adequate CNS concentrations are achieved in practice depends on model and administration route, and this is an empirical question rather than a solved one. For researchers designing CNS bioregulator studies, administration route and timing relative to any pharmacokinetic data are relevant design variables.

Research Context

Published Khavinson work on Cortagen examines neuronal protein synthesis, age-related changes in cortical gene expression, and neuroprotective effects in oxidative stress models. The cortex-specific transcriptional programs — involving neurotrophic factors, synaptic protein expression, and antioxidant enzyme production — are the proposed modulation targets. For comparative CNS peptide research, Cortagen can be studied alongside Pinealon (pineal/CNS target) within the Khavinson series.

Specifications

Storage: Lyophilized: −20°C, away from light. Once reconstituted: 2–8°C, use within 4 weeks.

Quality: HPLC purity analysis, mass spec identity confirmation, endotoxin testing on every batch. COA ships with every order. EU-based QC under CERTALAB S.R.L.

For research purposes only. Not for human consumption.