Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
KissPeptin-10
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Standard EU from €4.99 (RO) · core EU GLS €17.99 · Nordics/Baltics €12.99–€15.99 · Dispatched within 1–2 business days · Free shipping over €200.00 · no customs paperwork (EU) · via EU carrier network
€200.00 away from free shipping over €200.00. Under that, standard EU shipping is €17.99 (GLS, most of the EU).
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Research-grade KissPeptin-10. Class-level specification ≥98%; selected lots independently tested. Lyophilized powder in sealed glass vial. For research purposes only. Not for human consumption.
| Quantity | Price Each | Total | Savings |
|---|---|---|---|
| 1 unit | €25.49 | €25.49 | -- |
| 3+ | €24.22 | €72.65 | 5% off |
| 5+Most Popular | €22.94 | €114.71 | 10% off |
| 10+ | €21.67 | €216.67 | 15% off |
Important Notice
This product is intended for research purposes only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Due to legal and regulatory requirements, this product cannot be shipped to: Belgium, Croatia, Denmark, Italy, Lithuania, Poland, Portugal, Slovenia, and Sweden.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Published laboratory reports are available for selected lots. Check each report for its result and stated method. For research purposes only.
View report #233649 on janoshik.com →
Dispatched within 1–2 business days, shipping from €4.99 in Romania, from €12.99 across the rest of Europe
Class-level specification on record; independent Janoshik report on selected lots
About KissPeptin-10
Kisspeptin-10 is the minimum active fragment of the kisspeptin family -- a 10-amino acid C-terminal peptide derived from the KISS1 gene product. It binds the kisspeptin receptor (GPR54/KISS1R) and is the most potent naturally occurring kisspeptin isoform at this receptor. Kisspeptins are the most important upstream activators of GnRH neurons, making them the master regulators of reproductive function and central integrators of metabolic state with fertility.
The discovery of kisspeptin's role in GnRH regulation in 2003-2004 was a significant advance in reproductive endocrinology. Prior to this, the signal that drove GnRH neurons was not clearly identified. Kisspeptin neurons in the arcuate nucleus and the anteroventral periventricular nucleus receive metabolic and hormonal inputs -- leptin, sex steroids, thyroid hormones, metabolic state -- and translate these into GnRH drive. This makes kisspeptin the integration point between metabolic and reproductive signalling studied in models: how energy balance is coupled to GnRH drive, and how puberty timing relates to body weight in research models.
Research applications include stimulation testing of the HPG axis (kisspeptin-10 stimulation paradigm to assess GnRH neuron function), study of GnRH-axis signalling in hypothalamic hypogonadism models, and research into the neuroendocrine control of puberty and reproduction.
Specifications
| Parameter | Value |
|---|---|
| Compound | Kisspeptin-10 (KISS1 decapeptide, C-terminal fragment) |
| Purity | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Sterile water or saline |
| Storage | -20°C; 2-8°C after reconstitution |
Storage
Store at -20°C before reconstitution. Refrigerate at 2-8°C after reconstitution and use within 14 days. Protect from repeated freeze-thaw cycles.
How does kisspeptin control GnRH release?
Kisspeptin neurons in the hypothalamus (particularly in the arcuate nucleus for pulsatile GnRH regulation, and the anteroventral periventricular nucleus for the preovulatory LH surge) project directly to GnRH neurons, which express KISS1R. In research models, when kisspeptin binds KISS1R on GnRH neurons it is studied for its role in potently stimulating GnRH release. The arcuate kisspeptin neurons, which also co-express neurokinin B and dynorphin (KNDy neurons), are studied as the GnRH pulse generator -- the coordinated activity associated with pulsatile GnRH secretion that underlies LH and FSH secretion in model systems.
Why is kisspeptin important for understanding metabolic-reproductive connections?
Kisspeptin neurons receive input from leptin receptors, and leptin (the adipocyte hormone that signals nutritional adequacy) is required for normal kisspeptin neuron activity. In leptin-deficient or leptin-resistant states modelled in research, kisspeptin signaling is impaired and GnRH drive is reduced. This is studied to understand why severe nutritional restriction and extreme exercise suppress reproductive signalling in models -- the body uses kisspeptin as a gate through which metabolic status must pass before reproductive function proceeds. Kisspeptin research is central to understanding how energy balance and reproduction are coupled.
What is the kisspeptin stimulation paradigm?
The kisspeptin stimulation paradigm administers kisspeptin-10 (or kisspeptin-54) and measures LH, FSH, and testosterone/estradiol response. Unlike the standard GnRH stimulation paradigm which probes pituitary function, the kisspeptin paradigm examines the GnRH neuron and pituitary together -- it tests whether GnRH neurons can respond to kisspeptin and whether the pituitary can respond to the resulting GnRH release. This allows distinction between GnRH neuron dysfunction (no response to kisspeptin) and pituitary dysfunction (response to GnRH direct stimulation but not to kisspeptin). Research groups in the UK have published kisspeptin stimulation protocols.
Kisspeptin-10 is supplied for research purposes only. Not for human use. Handle in compliance with institutional biosafety guidelines.
Specification Summary
About KissPeptin-10
Kisspeptin-10 is the minimum active fragment of the kisspeptin family -- a 10-amino acid C-terminal peptide derived from the KISS1 gene product. It binds the kisspeptin receptor (GPR54/KISS1R) and is the most potent naturally occurring kisspeptin isoform at this receptor. Kisspeptins are the most important upstream activators of GnRH neurons, making them the master regulators of reproductive function and central integrators of metabolic state with fertility.
The discovery of kisspeptin's role in GnRH regulation in 2003-2004 was a significant advance in reproductive endocrinology. Prior to this, the signal that drove GnRH neurons was not clearly identified. Kisspeptin neurons in the arcuate nucleus and the anteroventral periventricular nucleus receive metabolic and hormonal inputs -- leptin, sex steroids, thyroid hormones, metabolic state -- and translate these into GnRH drive. This makes kisspeptin the integration point between metabolic and reproductive signalling studied in models: how energy balance is coupled to GnRH drive, and how puberty timing relates to body weight in research models.
Research applications include stimulation testing of the HPG axis (kisspeptin-10 stimulation paradigm to assess GnRH neuron function), study of GnRH-axis signalling in hypothalamic hypogonadism models, and research into the neuroendocrine control of puberty and reproduction.
Specifications
| Parameter | Value |
|---|---|
| Compound | Kisspeptin-10 (KISS1 decapeptide, C-terminal fragment) |
| Purity | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Sterile water or saline |
| Storage | -20°C; 2-8°C after reconstitution |
Storage
Store at -20°C before reconstitution. Refrigerate at 2-8°C after reconstitution and use within 14 days. Protect from repeated freeze-thaw cycles.
How does kisspeptin control GnRH release?
Kisspeptin neurons in the hypothalamus (particularly in the arcuate nucleus for pulsatile GnRH regulation, and the anteroventral periventricular nucleus for the preovulatory LH surge) project directly to GnRH neurons, which express KISS1R. In research models, when kisspeptin binds KISS1R on GnRH neurons it is studied for its role in potently stimulating GnRH release. The arcuate kisspeptin neurons, which also co-express neurokinin B and dynorphin (KNDy neurons), are studied as the GnRH pulse generator -- the coordinated activity associated with pulsatile GnRH secretion that underlies LH and FSH secretion in model systems.
Why is kisspeptin important for understanding metabolic-reproductive connections?
Kisspeptin neurons receive input from leptin receptors, and leptin (the adipocyte hormone that signals nutritional adequacy) is required for normal kisspeptin neuron activity. In leptin-deficient or leptin-resistant states modelled in research, kisspeptin signaling is impaired and GnRH drive is reduced. This is studied to understand why severe nutritional restriction and extreme exercise suppress reproductive signalling in models -- the body uses kisspeptin as a gate through which metabolic status must pass before reproductive function proceeds. Kisspeptin research is central to understanding how energy balance and reproduction are coupled.
What is the kisspeptin stimulation paradigm?
The kisspeptin stimulation paradigm administers kisspeptin-10 (or kisspeptin-54) and measures LH, FSH, and testosterone/estradiol response. Unlike the standard GnRH stimulation paradigm which probes pituitary function, the kisspeptin paradigm examines the GnRH neuron and pituitary together -- it tests whether GnRH neurons can respond to kisspeptin and whether the pituitary can respond to the resulting GnRH release. This allows distinction between GnRH neuron dysfunction (no response to kisspeptin) and pituitary dysfunction (response to GnRH direct stimulation but not to kisspeptin). Research groups in the UK have published kisspeptin stimulation protocols.
Kisspeptin-10 is supplied for research purposes only. Not for human use. Handle in compliance with institutional biosafety guidelines.
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every vial label carries a code. Look it up on our Verify page: it shows what CertaPeptides publishes for that code and, for a withdrawn lot, that the lot was withdrawn and why. If yours is withdrawn, or if the code on your label finds nothing, email us that code.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland). Delivery 1–15 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with escalation to ANPC and alternative dispute resolution (SAL) available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
