CNS Peptide Research Stack

About CNS Peptide Research Stack

What is the CNS Peptide Research Stack?
The CNS Peptide Research Stack bundles Selank and Semax — both developed at the Institute of Molecular Genetics of the Russian Academy of Sciences — with bacteriostatic water included. The two peptides work through different mechanisms that address different aspects of CNS signaling pathway research. Selank (a tuftsin analog) is primarily anxiolytic and immunomodulatory; Semax (an ACTH 4-10 analog) is primarily neurotrophic and neuroprotective. The combination covers both the anxiety/stress regulation side and the neurotrophic signaling/neuroprotection research side of CNS research in a single bundle.

Selank modulates GABAergic signaling and reduces anxiety-related behavior without the dependence or sedation associated with benzodiazepines. Semax drives BDNF and NGF upregulation, particularly in hippocampal tissue, and has been studied for CNS signaling effects and neuroprotection in ischemia models. Together they represent an interesting combination for researchers studying how anxiolytic and neurotrophic effects interact — whether anxiety reduction enhances neurotrophic signaling outcomes, whether BDNF changes affect anxiety measures, or simply whether the two mechanisms produce measurable combined effects beyond monotherapy.

Mechanism of Action

Stack Components

Compound 1Selank (tuftsin analog, GABA-A modulation, anxiolytic)
Compound 2Semax (ACTH 4-10 analog, BDNF upregulation, neurotrophic)
IncludedBacteriostatic water for reconstitution
Research originBoth from the Institute of Molecular Genetics, RAS

FAQ

What is the rationale for studying Selank and Semax together?

The combination addresses complementary but distinct aspects of CNS function. Selank's anxiolytic activity through GABA-A modulation and Semax's neurotrophic effects through BDNF/NGF upregulation represent different intervention points — anxiety regulation versus structural/plasticity support. In research models studying cognition, both factors are often relevant: stress and anxiety impair learning and memory consolidation, while neurotrophic factor levels directly affect synaptic plasticity. Whether the combination produces additive effects on behavioral or molecular outcomes is an empirical question, and studying them together in the same model is more informative than studying each in isolation if your question involves both anxiety and CNS pathway dimensions.

Research Overview

Storage
Store lyophilized at -20°C. Reconstitute separately with bacteriostatic water; stable at 4°C for up to 3 weeks after reconstitution. Label clearly — both are intranasal research peptides with similar administration routes.

Quality
HPLC purity analysis, mass spec identity confirmation, endotoxin testing on every batch. COA ships with every order. EU-based QC under CERTALAB S.R.L.

For research purposes only. Not for human consumption.

Product Specifications

• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• SKU: STACK-NOOT

Certificate of Analysis available for every batch. View COAs →

For research purposes only. Not for human consumption.