Forbindelse i forskningskvalitet. Kun til laboratoriebrug. Ikke beregnet til brug, indtagelse eller injektion hos mennesker eller dyr. Ingen medicinske påstande fremsættes eller antydes.
Adipotide
Gratis forsendelse på ordrer over €200
- Hvis et produkt ikke svarer til specifikationen på dets offentliggjorte COA, så kontakt os med dit batchnummer: vi undersøger det op mod batchens rapport og erstatter ethvert produkt, der ikke består, uden omkostninger for dig.
- Kontakt os inden for 48 timer efter levering med billeder af den ydre kasse, den indre emballage og eventuelle berørte hætteglas med læselige etiketter. Bekræftet transportskade erstattes uden omkostninger for dig.
3–7 dage til de fleste EU-lande · 10–14 dage til Norden og de baltiske lande
Standardfragt i EU fra 4,99 € (RO) · centrale EU-lande (GLS) 17,99 € · Norden og de baltiske lande 12,99 €–15,99 € · Afsendelse inden for 1–2 hverdage · Gratis fragt over 200,00 € · ingen toldpapirer (EU) · via netværket af fragtfirmaer i EU
200,00 € fra gratis fragt over 200,00 €. Derunder koster standardfragt i EU 17,99 € (GLS, de fleste EU-lande).
Sådan fungerer Paysera og SEPA
- Betal: Send en manuel SEPA-overførsel til den IBAN, vi sender dig på e-mail, eller, hvis muligheden tilbydes i kassen for din adresse, godkend en SEPA-overførsel i din egen bank via Payseras hostede side.
- Vi bekræfter: Paysera giver os besked med det samme, eller vi matcher en manuel overførsel med din ordre, når den modtages (normalt 1 hverdag).
- Vi afsender: Bekræftede ordrer afsendes typisk inden for 1-2 hverdage.
Kortbetalinger tilbydes ikke i øjeblikket. Der er ingen kortindløser tilknyttet denne kasse.
Research-grade Adipotide. Class-level specification ≥98%. Lyophilized powder in sealed glass vial. For laboratory research use only. Not for human consumption.
Vigtig meddelelse
Dette produkt er kun beregnet til laboratorie- og forskningsbrug. Ikke til human eller veterinær brug. Ved køb bekræfter du, at dette produkt udelukkende vil blive brugt til in vitro-forskningsformål.
På grund af juridiske og regulatoriske krav kan dette produkt ikke sendes til: Italien, Kroatien, Litauen og Slovenien.
Rekonstitution påkrævet
Dette peptid sendes lyofiliseret (tørt pulver) og kræver bakteriostatisk vand til rekonstitution før brug. BAC-vand sælges separat.
Hvornår dette produkt måske ikke passer til din forskning
- ⚠Hvis din forskning kræver materiale i GMP-kvalitet til kliniske anvendelser — peptider i forskningskvalitet er ikke beregnet til klinisk brug.
- ⚠Hvis dit laboratorium mangler korrekt kold opbevaring (-20°C-fryser) — dette peptids stabilitet kan blive forringet ved højere temperaturer.
- ⚠Hvis din studieprotokol kræver FDA-godkendte referencestandarder — kontakt USP eller en udbyder af certificeret referencemateriale.
Der er offentliggjort laboratorierapporter for udvalgte partier. Se hver rapport for resultatet og den angivne metode. Kun til forskningsformål.
Janoshik-rapport offentliggøres, når den er tilgængelig
Afsendelse inden for 1–2 hverdage, levering fra 4,99 € i Rumænien, fra 12,99 € i resten af Europa
Registreret specifikation på klasseniveau; uafhængig Janoshik-rapport på udvalgte partier
Om Adipotide
For research purposes only. Not for human or veterinary use.
Overview
Adipotide (also written as FTPP, or by its sequence CKGGRAKDC-GG-D(KLAKLAK)2) is a proapoptotic peptidomimetic built for vascular targeting of white adipose tissue. Two functional halves are joined in a single molecule: a homing peptide, CKGGRAKDC, that binds prohibitin displayed on the endothelium of blood vessels feeding white fat, and a proapoptotic domain, D(KLAKLAK)2, that disrupts mitochondrial membranes once it is internalised. The homing sequence was originally isolated through in vivo phage-display screening for peptides that localise to white adipose tissue vasculature, which is what gives the conjugate its tissue selectivity in research models.
The molecule was characterised by researchers at the University of Texas MD Anderson Cancer Center. It is frequently discussed as a conceptual parallel to antibody-drug conjugates: the cytotoxic payload is only delivered where the targeting element has bound, so activity is concentrated at the intended vascular bed rather than distributed systemically. CertaPeptides is a reseller and supplies Adipotide as a research reagent; we do not manufacture, formulate, or select the salt form of this compound.
Research Areas
Published literature has investigated Adipotide primarily as a tool for studying adipose-tissue vascular biology and the metabolic consequences of ablating fat-feeding vasculature. In the foundational mouse work, targeted ablation of adipose vasculature was used to study adipose-tissue remodelling and established prohibitin on adipose endothelium as an addressable target (Kolonin et al., 2004). A later non-human primate study examined tissue selectivity, metabolic parameters and renal markers (Barnhart et al., 2011). These two datasets remain the most cited reference points for researchers modelling vascular-targeting approaches to adipose tissue. Typical research questions include how selective prohibitin targeting is across different vascular beds, how model organisms respond to adipose vascular ablation, and how the conjugate format governs where apoptosis is triggered.
Specifications
| Compound | Adipotide / CKGGRAKDC-GG-D(KLAKLAK)2 |
|---|---|
| Purity | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Sterile water or PBS |
| Storage | −20°C lyophilized; 2–8°C after reconstitution, use within 14 days |
Quality & Verification
The class-level specification on record is ≥98%. No independent report is on record for this product yet; independent reports on selected lots are searchable by batch or report code at certapeptides.com/verify. We make no in-house testing claim and do not test every batch. EU-based handling under CERTALAB S.R.L.
Frequently Asked Questions
What is adipotide used for in research?
In the published literature, adipotide is used as a research tool to study vascular targeting of white adipose tissue. It combines a peptide that homes to prohibitin on adipose-feeding blood vessels with a proapoptotic domain, letting researchers investigate what happens in model systems when that specific vasculature is ablated. It is supplied for laboratory research only and is not for human or veterinary use.
How does adipotide target fat tissue specifically?
The CKGGRAKDC portion of the molecule was identified through in vivo phage-display screening for peptides that home to white adipose tissue vasculature. Its target, prohibitin, is displayed on the endothelium of fat-feeding vessels. Once the homing peptide binds, the D(KLAKLAK)2 domain is internalised and disrupts mitochondrial membranes, so activity is concentrated at the targeted vascular bed rather than distributed broadly.
What did the primate study report?
Barnhart and colleagues (2011, Science Translational Medicine) studied adipotide in rhesus monkeys, reporting on tissue selectivity, metabolic parameters and renal markers in the model animals. This primate dataset is the most advanced preclinical reference point cited for the compound.
What is a proapoptotic peptide-drug conjugate?
It is a molecule that pairs a targeting peptide with a cell-death-inducing payload, conceptually similar to an antibody-drug conjugate. In adipotide, the targeting peptide delivers the D(KLAKLAK)2 domain to adipose endothelial cells; the payload only acts where the targeting element has bound, which is the source of the conjugate's selectivity in research models.
How should adipotide be stored?
Store the lyophilized powder at −20°C, protected from light. After reconstitution with sterile water or PBS, keep refrigerated at 2–8°C and use within roughly 14 days. Handle in line with standard peptide-handling and institutional biosafety guidelines.
For research purposes only. Not for human consumption.
Specifikationsoversigt
Om Adipotide
For research purposes only. Not for human or veterinary use.
Overview
Adipotide (also written as FTPP, or by its sequence CKGGRAKDC-GG-D(KLAKLAK)2) is a proapoptotic peptidomimetic built for vascular targeting of white adipose tissue. Two functional halves are joined in a single molecule: a homing peptide, CKGGRAKDC, that binds prohibitin displayed on the endothelium of blood vessels feeding white fat, and a proapoptotic domain, D(KLAKLAK)2, that disrupts mitochondrial membranes once it is internalised. The homing sequence was originally isolated through in vivo phage-display screening for peptides that localise to white adipose tissue vasculature, which is what gives the conjugate its tissue selectivity in research models.
The molecule was characterised by researchers at the University of Texas MD Anderson Cancer Center. It is frequently discussed as a conceptual parallel to antibody-drug conjugates: the cytotoxic payload is only delivered where the targeting element has bound, so activity is concentrated at the intended vascular bed rather than distributed systemically. CertaPeptides is a reseller and supplies Adipotide as a research reagent; we do not manufacture, formulate, or select the salt form of this compound.
Research Areas
Published literature has investigated Adipotide primarily as a tool for studying adipose-tissue vascular biology and the metabolic consequences of ablating fat-feeding vasculature. In the foundational mouse work, targeted ablation of adipose vasculature was used to study adipose-tissue remodelling and established prohibitin on adipose endothelium as an addressable target (Kolonin et al., 2004). A later non-human primate study examined tissue selectivity, metabolic parameters and renal markers (Barnhart et al., 2011). These two datasets remain the most cited reference points for researchers modelling vascular-targeting approaches to adipose tissue. Typical research questions include how selective prohibitin targeting is across different vascular beds, how model organisms respond to adipose vascular ablation, and how the conjugate format governs where apoptosis is triggered.
Specifications
| Compound | Adipotide / CKGGRAKDC-GG-D(KLAKLAK)2 |
|---|---|
| Purity | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Sterile water or PBS |
| Storage | −20°C lyophilized; 2–8°C after reconstitution, use within 14 days |
Quality & Verification
The class-level specification on record is ≥98%. No independent report is on record for this product yet; independent reports on selected lots are searchable by batch or report code at certapeptides.com/verify. We make no in-house testing claim and do not test every batch. EU-based handling under CERTALAB S.R.L.
Frequently Asked Questions
What is adipotide used for in research?
In the published literature, adipotide is used as a research tool to study vascular targeting of white adipose tissue. It combines a peptide that homes to prohibitin on adipose-feeding blood vessels with a proapoptotic domain, letting researchers investigate what happens in model systems when that specific vasculature is ablated. It is supplied for laboratory research only and is not for human or veterinary use.
How does adipotide target fat tissue specifically?
The CKGGRAKDC portion of the molecule was identified through in vivo phage-display screening for peptides that home to white adipose tissue vasculature. Its target, prohibitin, is displayed on the endothelium of fat-feeding vessels. Once the homing peptide binds, the D(KLAKLAK)2 domain is internalised and disrupts mitochondrial membranes, so activity is concentrated at the targeted vascular bed rather than distributed broadly.
What did the primate study report?
Barnhart and colleagues (2011, Science Translational Medicine) studied adipotide in rhesus monkeys, reporting on tissue selectivity, metabolic parameters and renal markers in the model animals. This primate dataset is the most advanced preclinical reference point cited for the compound.
What is a proapoptotic peptide-drug conjugate?
It is a molecule that pairs a targeting peptide with a cell-death-inducing payload, conceptually similar to an antibody-drug conjugate. In adipotide, the targeting peptide delivers the D(KLAKLAK)2 domain to adipose endothelial cells; the payload only acts where the targeting element has bound, which is the source of the conjugate's selectivity in research models.
How should adipotide be stored?
Store the lyophilized powder at −20°C, protected from light. After reconstitution with sterile water or PBS, keep refrigerated at 2–8°C and use within roughly 14 days. Handle in line with standard peptide-handling and institutional biosafety guidelines.
For research purposes only. Not for human consumption.
Relateret forskningslæsning
Objektive sammenligninger og forskningsguides om denne forbindelse. Referencemateriale kun til forskningsbrug.
Forskertillid
Hvorfor forskere vælger CertaPeptides
Hvem tester det egentlig?
Udvalgte partier verificeres uafhængigt af Janoshik Analytical (Tjekkiet) og offentliggøres på Janoshiks offentlige portal. Andre partier leveres med leverandørens batchspecifikation. Se /coa for den offentliggjorte væg.
Se COA'er →Hvad hvis jeg får det forkerte parti?
Etiketten på hvert hætteglas bærer en kode. Slå den op på vores verifikationsside: Siden viser, hvad CertaPeptides offentliggør for koden, og for et tilbagetrukket parti, at partiet er trukket tilbage, og hvorfor. Er dit parti trukket tilbage, eller giver koden på din etiket intet resultat, så send os den kode på e-mail.
Se COA'er →Hvor afsendes det fra?
Rumænien (EU). Vi er CERTALAB SRL, CUI 54169956, momsregistreret. Sameday for Rumænien, GLS til de fleste EU-destinationer, TCE Worldwide for de øvrige grænseoverskridende markeder i og uden for EU (Storbritannien, Schweiz). Levering 1–15 hverdage afhængigt af destination — det præcise interval vises ved kassen.
Forsendelsesdetaljer →Hvad hvis der er et problem?
Du har 14 dages fortrydelsesret i henhold til OUG 34/2014 (rumænsk/EU-forbrugerlovgivning), med mulighed for eskalering til ANPC og for alternativ tvistbilæggelse (SAL). Kontakt os på support@certapeptides.com.
Returpolitik →Produktinformation
Dette produkt er udelukkende beregnet til videnskabelig forskning og udvikling. Det er et kemisk stof, der ikke må anvendes som lægemiddel, medicin, aktivt stof eller ingrediens i noget produkt beregnet til konsum hos mennesker eller dyr. Forskere skal håndtere denne forbindelse i overensstemmelse med deres institutions biosikkerhedsretningslinjer. Må kun anvendes i korrekt udstyrede laboratoriemiljøer med passende personlige værnemidler.
