Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
≥98% PurityIn-House HPLC & MS Tested
GLP-1 and Incretin Research PeptidesSKU: CP-ORF
Orforglipron
≥99% PurityHPLC & MS verified
From €188.99Out of Stock
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Research-grade Orforglipron. 99.3% avg purity, HPLC & MS verified. Oral tablets in sealed bottle. For laboratory research use only. Not for human consumption.
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Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Purity HPLC
99.3% average HPLC purity, verified by independent third-party testing
Third-Party Tested
Janoshik report published when available
Fast Shipping
24h dispatch, EU-wide shipping from €4.99
Third-Party Tested
Independent lab verification for every batch
Last reviewed: 2026-04-24
About Orforglipron
Everything else in the GLP-1 class is an injectable peptide. Orforglipron is not. It's a small-molecule oral GLP-1 receptor agonist from the drug sponsor — not a modified peptide with an absorption enhancer like oral semaglutide (Rybelsus), but a genuine non-peptide small molecule activating the GLP-1 receptor through a different binding site. CAS: 2308826-67-5. MW 527.6 Da. Capsule form. Room temperature stable. No cold chain, no reconstitution, no injection. That's a different compound class from every other GLP-1 agonist in research use.
Why the Mechanism Matters
GLP-1 peptides bind the receptor's extracellular domain. Orforglipron, as a small molecule, likely occupies the transmembrane allosteric site — the typical binding mode for small-molecule GPCR modulators. Different binding sites can produce different signaling outputs: biased agonism, different receptor trafficking, altered downstream pathway engagement. Whether orforglipron exhibits meaningful signaling bias versus peptide agonists is an active research question that only exists because the compound is chemically distinct.
The distinction from oral semaglutide is also worth being precise about. Rybelsus is oral semaglutide: still a GLP-1 peptide, using SNAC to survive the GI tract. Orforglipron is chemically unrelated to any GLP-1 peptide — different chemistry, different pharmacokinetics, different receptor binding site, and potentially different signaling profile. The two oral formats are not equivalent research tools. Phase 2 data showed dose-dependent efficacy with metabolic endpoint changes comparable to injectable semaglutide in some cohorts. Oral bioavailability also changes study design: no injection timing variables, no subcutaneous absorption variability, simpler administration in complex experimental setups.
Specifications
| Molecular Weight | 527.6 Da |
|---|---|
| CAS | 2308826-67-5 |
| Purity | 99.3% avg by HPLC |
| Form | Capsule |
| Sizes | 5mg (30 capsules), 12mg |
Storage: Room temperature, away from moisture and direct light.
Quality: HPLC purity analysis, mass spec identity confirmation, endotoxin testing on every batch. COA ships with every order. EU-based QC under CERTALAB S.R.L.
Frequently Asked Questions
How is orforglipron different from oral semaglutide?
Oral semaglutide (Rybelsus) is still a GLP-1 peptide — it uses SNAC (sodium N-[8-(2-hydroxybenzoyl)amino] caprylate) to survive gastrointestinal conditions. Orforglipron is a small molecule, chemically unrelated to any GLP-1 peptide. It likely binds the GLP-1 receptor at a transmembrane allosteric site rather than the extracellular peptide-binding domain. The two compounds are pharmacologically distinct despite both being "oral GLP-1."
What research applications is orforglipron suited for?
Small-molecule GLP-1R pharmacology and biased agonism studies are the primary applications — specifically comparing receptor signaling between small-molecule and peptide agonists at the same receptor. The oral bioavailability also makes it useful for studies where injection variables need to be eliminated. Standard metabolic endpoint research in GLP-1R biology is a secondary application.
For research purposes only. Not for human consumption.
Specification Summary
Purity99.3% avg
FormLyophilized Powder
Storage-20\u00B0C
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Every batch is independently verified by Janoshik Analytical (100,000+ verifications/month), Eurofins Scientific, and Analytical Sciences International. We publish every Certificate of Analysis.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI RO54451735, VAT-registered. SameDay for Romania, FanCourier for Central/Eastern EU, TCE Worldwide for the rest. 3–7 business days EU-wide.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
Frequently Asked
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