BAM15 Capsule 50mg

BAM15 is a selective mitochondrial uncoupler -- a compound that dissipates the proton gradient across the inner mitochondrial membrane without affecting the plasma membrane potential. That selectivity is the key feature distinguishing it from older uncouplers. Classical compounds like DNP (2,4-dinitrophenol) and FCCP are effective but indiscriminate: they disrupt proton gradients across any phospholipid bilayer, including the plasma membrane. The consequences are dose-limiting toxicity including hyperthermia, cardiovascular instability, and cell death. BAM15's chemical structure selectively targets the mitochondrial inner membrane, producing controlled proton leak without off-target membrane depolarization.

The research value is in studying energy expenditure and metabolic flexibility. When the mitochondrial proton gradient is dissipated, cells must increase substrate oxidation to maintain ATP levels -- essentially burning more fuel. In preclinical models, BAM15 increases energy expenditure and modulates adipose tissue metabolism without the metabolic adaptation plateau or muscle catabolism associated with caloric restriction. For researchers studying thermogenesis, mitochondrial biology, or metabolic syndrome models, it provides a cleaner research tool than any previous uncoupler. Each capsule provides 50mg.

Research Applications

BAM15 is used in research on mitochondrial uncoupling mechanisms, thermogenesis and energy expenditure, adipose tissue biology, metabolic syndrome and obesity models, and as a cleaner alternative to FCCP or DNP in studies requiring controlled uncoupling without off-target toxicity.

Specifications

Storage

Store at room temperature in a cool, dry place away from light. BAM15 is a small molecule with good ambient stability. Protect from moisture and direct light exposure.

BAM15 Capsule is supplied for laboratory research use only. Not approved for human use. Handle in compliance with institutional biosafety guidelines.