Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
≥98% PurityIn-House HPLC & MS Tested
Growth FactorsSKU: CP-FMP2
PEG MGF 2mg
≥99% PurityHPLC & MS verified
Research Reference
peptidesdb.org
/p/peg-mgf
€39.99Out of Stock
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Research-grade PEG MGF. 99.3% avg purity, HPLC & MS verified. Lyophilized powder in sealed glass vial. For laboratory research use only. Not for human consumption.
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Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Purity HPLC
99.3% average HPLC purity, verified by independent third-party testing
Third-Party Tested
Janoshik report published when available
Fast Shipping
24h dispatch, EU-wide shipping from €4.99
Third-Party Tested
Independent lab verification for every batch
Last reviewed: 2026-04-05
About PEG MGF 2mg
PEGylated Mechano Growth Factor is a modified form of MGF (a splice variant of IGF-1) stabilized by polyethylene glycol conjugation. The PEG modification extends the half-life substantially -- native MGF has a very short plasma half-life (minutes to hours) that limits its utility in systemic research contexts. PEGylation typically extends this to 24+ hours, enabling once-daily or even less frequent dosing in animal models. Each vial contains 2mg.
MGF (Mechano Growth Factor) is derived from the IGF-1 gene through alternative splicing. When muscle is subjected to mechanical load, this splice variant is preferentially expressed over systemic IGF-1. The MGF E-peptide (the C-terminal extension unique to this splice form) is responsible for most of its distinct biology -- particularly its role in activating muscle satellite cells (stem cells resident in skeletal muscle). Satellite cell activation is the initiating step in muscle repair after injury. Native MGF's extreme instability in physiological fluids is the primary reason PEGylated forms are used for systemic administration research.
The biological question being addressed with PEG-MGF is whether systemic delivery of a stabilized MGF form can reproduce the local satellite cell activation that normally occurs in response to mechanical loading -- and whether this has applications in muscle wasting, aging, or injury recovery research.
Research Applications
PEG-MGF is used in research on satellite cell biology, muscle regeneration and repair, muscle wasting (sarcopenia, cachexia), IGF-1 splice variant pharmacology, and the role of mechanical loading signals in muscle adaptation.
Specifications
| Parameter | Value |
|---|---|
| Compound | PEGylated Mechano Growth Factor |
| Amount per Vial | 2mg |
| Purity | 99.3% avg (HPLC verified) |
| Format | Lyophilized powder |
| Reconstitution | Bacteriostatic water |
| Storage | -20°C; 2-8°C after reconstitution |
Storage
Store at -20°C before reconstitution. After reconstitution with bacteriostatic water, refrigerate at 2-8°C. Use within 28 days. Avoid vigorous shaking during reconstitution -- gentle rolling is sufficient to dissolve the lyophilized cake.
Why does PEGylation matter for MGF research?
Native MGF has a plasma half-life of minutes, which makes it impractical for systemic administration research. The peptide is rapidly degraded before it can produce measurable effects at distant tissues. PEGylation -- attachment of polyethylene glycol chains -- shields the peptide from proteolytic degradation and renal clearance, extending half-life to 24+ hours. This allows meaningful plasma concentrations to be maintained with manageable dosing frequency in animal models. Without PEGylation, most MGF research uses local injection directly into target muscle tissue.
What is the difference between MGF and IGF-1?
MGF and systemic IGF-1 are both encoded by the IGF-1 gene but differ in how they are spliced. When skeletal muscle experiences mechanical load or damage, alternative splicing produces MGF with a unique C-terminal E-peptide sequence. This E-peptide is not present in systemic IGF-1 and is responsible for MGF's satellite cell-activating properties. Systemic IGF-1 promotes muscle protein synthesis and has anabolic effects, but MGF's role in satellite cell activation for repair is mechanistically distinct and not replicated by IGF-1.
What are muscle satellite cells and why is their activation important?
Satellite cells are muscle stem cells that reside quiescent beneath the basal lamina of muscle fibers. When muscle is damaged or overloaded, they activate, proliferate, and fuse with existing or new fibers to repair and hypertrophy the muscle. This is the primary mechanism of post-injury regeneration. Declining satellite cell activity with aging (sarcopenia) and in muscle wasting conditions is a research focus for understanding why muscle repair becomes less effective. MGF's role in activating these cells makes it a research tool for studying satellite cell biology and potential interventions for muscle wasting.
PEG MGF is supplied for laboratory research use only. Not approved for human use. Handle in compliance with institutional biosafety guidelines.
Specification Summary
Purity99.3% avg
FormLyophilized Powder
Storage-20\u00B0C
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic, ISO 17025) and published on the Janoshik public portal. Other lots ship with our manufacturing batch specification (CERTALAB Internal QC). See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI RO54451735, VAT-registered. Sameday for Romania, FAN Courier for Central/Eastern EU + Italy + Baltics, TCE Worldwide for the rest of the EU and non-EU markets (UK, Switzerland, Norway, Iceland, Israel). Delivery 1–14 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
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