Research-grade compound. Laboratory use only. Not intended for human or animal use, ingestion, or injection. No medical claims are made or implied.
≥98% PurityIn-House HPLC & MS Tested
Growth FactorsSKU: CP-FM2
MGF 2mg
≥99% PurityHPLC & MS verified
Research Reference
peptidesdb.org
/p/mgf
€17.99Out of Stock
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Research-grade MGF. 99.3% avg purity, HPLC & MS verified. Lyophilized powder in sealed glass vial. For laboratory research use only. Not for human consumption.
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Important Notice
This product is intended for laboratory and research use only. Not for human or veterinary use. By purchasing, you confirm this product will be used exclusively for in-vitro research purposes.
Reconstitution Required
This peptide ships lyophilized (dry powder) and requires bacteriostatic water to reconstitute before use. BAC water is sold separately.
When This Product May Not Suit Your Research
- ⚠If your research requires GMP-grade material for clinical applications — research-grade peptides are not intended for clinical use.
- ⚠If your lab lacks proper cold storage (-20°C freezer) — this peptide's stability may be compromised at higher temperatures.
- ⚠If your study protocol requires FDA-approved reference standards — contact USP or a certified reference material provider.
Purity HPLC
99.3% average HPLC purity, verified by independent third-party testing
Third-Party Tested
Janoshik report published when available
Fast Shipping
24h dispatch, EU-wide shipping from €4.99
Third-Party Tested
Independent lab verification for every batch
Last reviewed: 2026-04-05
About MGF 2mg
Mechano Growth Factor (MGF) is an alternatively spliced variant of the IGF-1 gene expressed preferentially in skeletal muscle in response to mechanical loading or injury. The C-terminal E-peptide sequence unique to MGF is responsible for its distinctive biological activity -- specifically its ability to activate muscle satellite cells, the resident stem cells of skeletal muscle. Each vial contains 2mg of the native (non-PEGylated) MGF peptide.
The key thing to understand about native MGF is its instability in physiological fluids. Native MGF has a plasma half-life measured in minutes, which means it is degraded rapidly after systemic administration. This isn't necessarily a problem for all research designs -- local intramuscular injection delivers the peptide directly to the target tissue where satellite cells reside, bypassing the stability problem. For research focused on local muscle biology, native MGF at the injection site has the advantage of physiological route of action and no PEG modification to complicate interpretation.
The contrast between native MGF and PEG-MGF represents a meaningful research design choice. Native MGF better reflects what happens in the muscle microenvironment after mechanical loading. PEG-MGF allows for systemic administration and longer exposure times. Both approaches have their place depending on the research question.
Research Applications
Native MGF is used in research on satellite cell activation and muscle regeneration, local intramuscular peptide pharmacology, IGF-1 splice variant biology, muscle repair after acute injury, and as a comparator to PEG-MGF for understanding how stability affects biological outcomes.
Specifications
| Parameter | Value |
|---|---|
| Compound | Mechano Growth Factor (IGF-1 Ec splice variant) |
| Amount per Vial | 2mg |
| Purity | 99.3% avg (HPLC verified) |
| Format | Lyophilized powder |
| Reconstitution | Sterile or bacteriostatic water |
| Storage | -20°C; 2-8°C after reconstitution, use within 7 days |
Storage
Store at -20°C before reconstitution. Due to its instability, native MGF reconstituted solutions should be used quickly -- within 7 days at 2-8°C. Minimize freeze-thaw cycles. For studies where longer stable supply is needed, PEG-MGF is available as an alternative.
When should I use native MGF versus PEG-MGF?
Use native MGF for local intramuscular injection studies where the goal is to study satellite cell activation in the injected muscle tissue -- this mirrors the physiological context of mechanical load-induced MGF expression. The short half-life is less of a problem when delivering directly to target tissue. Use PEG-MGF for systemic administration studies where sustained plasma concentrations are needed, or for studies where once-daily or less frequent dosing is required. PEG-MGF better suits experiments looking at whole-body effects or cross-muscle signaling.
How quickly is native MGF degraded in vivo?
Native MGF has a plasma half-life of approximately a few minutes. After systemic (IV or SC) injection, it is cleared very rapidly by proteolytic degradation and renal filtration. In the local muscle microenvironment after intramuscular injection, the effective exposure time is longer because the peptide is partially protected from circulating proteases, but this is still measured in hours rather than days. This instability is the main limitation of native MGF for systemic research applications and the reason PEGylated forms were developed.
What happens when satellite cells are activated by MGF?
Satellite cells normally exist in a quiescent state beneath the muscle fiber basal lamina. MGF E-peptide binding activates these cells, causing them to proliferate (producing a larger pool of myogenic progenitors) and then differentiate -- fusing with existing muscle fibers to add new myonuclei, or forming entirely new fibers. This process is essential for muscle repair after injury and for hypertrophy in response to training load. MGF acts upstream of IGF-1 signaling in this cascade, with IGF-1 taking over the differentiation phase after satellite cells have been activated by MGF.
MGF is supplied for laboratory research use only. Not approved for human use. Handle in compliance with institutional biosafety guidelines.
Specification Summary
Purity99.3% avg
FormLyophilized Powder
Storage-20\u00B0C
Researcher Confidence
Why researchers choose CertaPeptides
Who actually tests this?
Selected lots are independently verified by Janoshik Analytical (Czech Republic, ISO 17025) and published on the Janoshik public portal. Other lots ship with our manufacturing batch specification (CERTALAB Internal QC). See /coa for the published wall.
View COAs →What if I get the wrong batch?
Every bottle label carries a lot number that maps to a specific Certificate of Analysis. If a batch fails spec, we don't ship it — full stop.
View COAs →Where does it ship from?
Romania (EU). We are CERTALAB SRL, CUI RO54451735, VAT-registered. Sameday for Romania, FAN Courier for Central/Eastern EU + Italy + Baltics, TCE Worldwide for the rest of the EU and non-EU markets (UK, Switzerland, Norway, Iceland, Israel). Delivery 1–14 business days depending on destination — exact window shown at checkout.
Shipping details →What if there's a problem?
You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with ANPC/ODR escalation available. Contact us at support@certapeptides.com.
Returns policy →Product Information
This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.
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