Spoj istraživačke kvalitete. Samo za laboratorijsku uporabu. Nije namijenjen za ljudsku ni životinjsku uporabu, gutanje ili injiciranje. Ne iznose se niti impliciraju nikakve medicinske tvrdnje.
Adipotide
Besplatna dostava za narudžbe iznad €200
- Ako proizvod ne odgovara specifikaciji na svojem objavljenom COA-u, obratite nam se s brojem serije: provjeravamo prema izvješću serije i zamjenjujemo svaki proizvod koji ga ne zadovoljava, bez ikakvih troškova za vas.
- Obratite nam se u roku od 48 sati od dostave s fotografijama vanjske kutije, unutarnjeg pakiranja i svih zahvaćenih bočica s čitljivim etiketama. Potvrđena oštećenja u prijevozu zamjenjuju se bez troškova za vas.
3–7 dana za većinu država EU-a · 10–14 dana za nordijske zemlje i baltičke države
Standardna dostava u EU-u od 4,99 € (RO) · glavne zemlje EU-a (GLS) 17,99 € · nordijske zemlje i baltičke države 12,99 €–15,99 € · Otprema u roku od 1–2 radna dana · Besplatna dostava iznad 200,00 € · bez carinske dokumentacije (EU) · putem mreže prijevoznika u EU-u
Još 200,00 € do besplatne dostave iznad 200,00 €. Ispod tog iznosa standardna dostava u EU-u iznosi 17,99 € (GLS, većina država EU-a).
Kako funkcioniraju Paysera i SEPA
- Platite: pošaljite ručni SEPA prijenos na IBAN koji vam šaljemo e-poštom ili odobrite SEPA prijenos u vlastitoj banci putem Paysera hostirane stranice, ako blagajna nudi tu mogućnost za vašu adresu.
- Potvrđujemo: Paysera nas odmah obavještava ili ručni prijenos uparujemo s narudžbom kada stigne (obično 1 radni dan).
- Otpremamo: potvrđene narudžbe obično se otpremaju u roku od 1-2 radna dana.
Plaćanje karticom trenutno nije dostupno. Ova blagajna nema procesor za kartična plaćanja.
Research-grade Adipotide. Class-level specification ≥98%. Lyophilized powder in sealed glass vial. For laboratory research use only. Not for human consumption.
Važna napomena
Ovaj je proizvod namijenjen isključivo za laboratorijsku i istraživačku uporabu. Nije za ljudsku ni veterinarsku uporabu. Kupnjom potvrđujete da će se ovaj proizvod koristiti isključivo za in-vitro istraživačke svrhe.
Zbog zakonskih i regulatornih zahtjeva ovaj se proizvod ne može slati u: Hrvatska, Italija, Litva i Slovenija.
Potrebna rekonstitucija
Ovaj se peptid otprema liofiliziran (suhi prašak) i zahtijeva bakteriostatsku vodu za rekonstituciju prije uporabe. BAC voda prodaje se zasebno.
Kada ovaj proizvod možda nije prikladan za Vaše istraživanje
- ⚠Ako Vaše istraživanje zahtijeva materijal GMP kvalitete za kliničke primjene — peptidi istraživačke kvalitete nisu namijenjeni za kliničku uporabu.
- ⚠Ako Vaš laboratorij nema odgovarajuće hladno čuvanje (zamrzivač na -20°C) — stabilnost ovog peptida može biti narušena na višim temperaturama.
- ⚠Ako Vaš protokol studije zahtijeva referentne standarde odobrene od FDA — obratite se USP-u ili pružatelju certificiranog referentnog materijala.
Za odabrane serije dostupna su objavljena laboratorijska izvješća. U svakom izvješću provjerite rezultat i navedenu metodu. Samo u istraživačke svrhe.
Izvješće Janoshik objavljuje se kada bude dostupno
Otprema unutar 1–2 radna dana, dostava od 4,99 € u Rumunjskoj, od 12,99 € u ostatku Europe
Evidentirana specifikacija na razini klase; neovisno izvješće Janoshik za odabrane serije
O proizvodu Adipotide
For research purposes only. Not for human or veterinary use.
Overview
Adipotide (also written as FTPP, or by its sequence CKGGRAKDC-GG-D(KLAKLAK)2) is a proapoptotic peptidomimetic built for vascular targeting of white adipose tissue. Two functional halves are joined in a single molecule: a homing peptide, CKGGRAKDC, that binds prohibitin displayed on the endothelium of blood vessels feeding white fat, and a proapoptotic domain, D(KLAKLAK)2, that disrupts mitochondrial membranes once it is internalised. The homing sequence was originally isolated through in vivo phage-display screening for peptides that localise to white adipose tissue vasculature, which is what gives the conjugate its tissue selectivity in research models.
The molecule was characterised by researchers at the University of Texas MD Anderson Cancer Center. It is frequently discussed as a conceptual parallel to antibody-drug conjugates: the cytotoxic payload is only delivered where the targeting element has bound, so activity is concentrated at the intended vascular bed rather than distributed systemically. CertaPeptides is a reseller and supplies Adipotide as a research reagent; we do not manufacture, formulate, or select the salt form of this compound.
Research Areas
Published literature has investigated Adipotide primarily as a tool for studying adipose-tissue vascular biology and the metabolic consequences of ablating fat-feeding vasculature. In the foundational mouse work, targeted ablation of adipose vasculature was used to study adipose-tissue remodelling and established prohibitin on adipose endothelium as an addressable target (Kolonin et al., 2004). A later non-human primate study examined tissue selectivity, metabolic parameters and renal markers (Barnhart et al., 2011). These two datasets remain the most cited reference points for researchers modelling vascular-targeting approaches to adipose tissue. Typical research questions include how selective prohibitin targeting is across different vascular beds, how model organisms respond to adipose vascular ablation, and how the conjugate format governs where apoptosis is triggered.
Specifications
| Compound | Adipotide / CKGGRAKDC-GG-D(KLAKLAK)2 |
|---|---|
| Purity | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Sterile water or PBS |
| Storage | −20°C lyophilized; 2–8°C after reconstitution, use within 14 days |
Quality & Verification
The class-level specification on record is ≥98%. No independent report is on record for this product yet; independent reports on selected lots are searchable by batch or report code at certapeptides.com/verify. We make no in-house testing claim and do not test every batch. EU-based handling under CERTALAB S.R.L.
Frequently Asked Questions
What is adipotide used for in research?
In the published literature, adipotide is used as a research tool to study vascular targeting of white adipose tissue. It combines a peptide that homes to prohibitin on adipose-feeding blood vessels with a proapoptotic domain, letting researchers investigate what happens in model systems when that specific vasculature is ablated. It is supplied for laboratory research only and is not for human or veterinary use.
How does adipotide target fat tissue specifically?
The CKGGRAKDC portion of the molecule was identified through in vivo phage-display screening for peptides that home to white adipose tissue vasculature. Its target, prohibitin, is displayed on the endothelium of fat-feeding vessels. Once the homing peptide binds, the D(KLAKLAK)2 domain is internalised and disrupts mitochondrial membranes, so activity is concentrated at the targeted vascular bed rather than distributed broadly.
What did the primate study report?
Barnhart and colleagues (2011, Science Translational Medicine) studied adipotide in rhesus monkeys, reporting on tissue selectivity, metabolic parameters and renal markers in the model animals. This primate dataset is the most advanced preclinical reference point cited for the compound.
What is a proapoptotic peptide-drug conjugate?
It is a molecule that pairs a targeting peptide with a cell-death-inducing payload, conceptually similar to an antibody-drug conjugate. In adipotide, the targeting peptide delivers the D(KLAKLAK)2 domain to adipose endothelial cells; the payload only acts where the targeting element has bound, which is the source of the conjugate's selectivity in research models.
How should adipotide be stored?
Store the lyophilized powder at −20°C, protected from light. After reconstitution with sterile water or PBS, keep refrigerated at 2–8°C and use within roughly 14 days. Handle in line with standard peptide-handling and institutional biosafety guidelines.
For research purposes only. Not for human consumption.
Sažetak specifikacije
O proizvodu Adipotide
For research purposes only. Not for human or veterinary use.
Overview
Adipotide (also written as FTPP, or by its sequence CKGGRAKDC-GG-D(KLAKLAK)2) is a proapoptotic peptidomimetic built for vascular targeting of white adipose tissue. Two functional halves are joined in a single molecule: a homing peptide, CKGGRAKDC, that binds prohibitin displayed on the endothelium of blood vessels feeding white fat, and a proapoptotic domain, D(KLAKLAK)2, that disrupts mitochondrial membranes once it is internalised. The homing sequence was originally isolated through in vivo phage-display screening for peptides that localise to white adipose tissue vasculature, which is what gives the conjugate its tissue selectivity in research models.
The molecule was characterised by researchers at the University of Texas MD Anderson Cancer Center. It is frequently discussed as a conceptual parallel to antibody-drug conjugates: the cytotoxic payload is only delivered where the targeting element has bound, so activity is concentrated at the intended vascular bed rather than distributed systemically. CertaPeptides is a reseller and supplies Adipotide as a research reagent; we do not manufacture, formulate, or select the salt form of this compound.
Research Areas
Published literature has investigated Adipotide primarily as a tool for studying adipose-tissue vascular biology and the metabolic consequences of ablating fat-feeding vasculature. In the foundational mouse work, targeted ablation of adipose vasculature was used to study adipose-tissue remodelling and established prohibitin on adipose endothelium as an addressable target (Kolonin et al., 2004). A later non-human primate study examined tissue selectivity, metabolic parameters and renal markers (Barnhart et al., 2011). These two datasets remain the most cited reference points for researchers modelling vascular-targeting approaches to adipose tissue. Typical research questions include how selective prohibitin targeting is across different vascular beds, how model organisms respond to adipose vascular ablation, and how the conjugate format governs where apoptosis is triggered.
Specifications
| Compound | Adipotide / CKGGRAKDC-GG-D(KLAKLAK)2 |
|---|---|
| Purity | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Sterile water or PBS |
| Storage | −20°C lyophilized; 2–8°C after reconstitution, use within 14 days |
Quality & Verification
The class-level specification on record is ≥98%. No independent report is on record for this product yet; independent reports on selected lots are searchable by batch or report code at certapeptides.com/verify. We make no in-house testing claim and do not test every batch. EU-based handling under CERTALAB S.R.L.
Frequently Asked Questions
What is adipotide used for in research?
In the published literature, adipotide is used as a research tool to study vascular targeting of white adipose tissue. It combines a peptide that homes to prohibitin on adipose-feeding blood vessels with a proapoptotic domain, letting researchers investigate what happens in model systems when that specific vasculature is ablated. It is supplied for laboratory research only and is not for human or veterinary use.
How does adipotide target fat tissue specifically?
The CKGGRAKDC portion of the molecule was identified through in vivo phage-display screening for peptides that home to white adipose tissue vasculature. Its target, prohibitin, is displayed on the endothelium of fat-feeding vessels. Once the homing peptide binds, the D(KLAKLAK)2 domain is internalised and disrupts mitochondrial membranes, so activity is concentrated at the targeted vascular bed rather than distributed broadly.
What did the primate study report?
Barnhart and colleagues (2011, Science Translational Medicine) studied adipotide in rhesus monkeys, reporting on tissue selectivity, metabolic parameters and renal markers in the model animals. This primate dataset is the most advanced preclinical reference point cited for the compound.
What is a proapoptotic peptide-drug conjugate?
It is a molecule that pairs a targeting peptide with a cell-death-inducing payload, conceptually similar to an antibody-drug conjugate. In adipotide, the targeting peptide delivers the D(KLAKLAK)2 domain to adipose endothelial cells; the payload only acts where the targeting element has bound, which is the source of the conjugate's selectivity in research models.
How should adipotide be stored?
Store the lyophilized powder at −20°C, protected from light. After reconstitution with sterile water or PBS, keep refrigerated at 2–8°C and use within roughly 14 days. Handle in line with standard peptide-handling and institutional biosafety guidelines.
For research purposes only. Not for human consumption.
Povezano istraživačko štivo
Objektivne usporedbe i istraživački vodiči o ovom spoju. Referentni materijal isključivo za istraživačku uporabu.
Povjerenje istraživača
Zašto istraživači biraju CertaPeptides
Tko zapravo testira ovo?
Odabrane serije neovisno provjerava Janoshik Analytical (Češka) i objavljuju se na javnom portalu Janoshik. Ostale serije otpremaju se sa specifikacijom serije dobavljača. Objavljeni pregled pogledajte na /coa.
Pogledaj COA →Što ako dobijem pogrešnu seriju?
Svaka naljepnica bočice nosi kod. Potražite ga na našoj stranici za provjeru: ona prikazuje ono što CertaPeptides objavljuje za taj kod, a za povučenu seriju i to da je serija povučena te zašto. Ako je vaša serija povučena ili ako pretraga koda s vaše naljepnice ne pronađe ništa, pošaljite nam taj kod e-poštom.
Pogledaj COA →Odakle se otprema?
Rumunjska (EU). Mi smo CERTALAB SRL, CUI 54169956, registrirani za PDV. Sameday za Rumunjsku, GLS za većinu odredišta u EU-u, TCE Worldwide za ostala prekogranična tržišta EU-a i izvan EU-a (Ujedinjeno Kraljevstvo, Švicarska). Dostava 1–15 radnih dana ovisno o odredištu — točan rok prikazan je na blagajni.
Detalji dostave →Što ako se pojavi problem?
Imate pravo na odustajanje u roku od 14 dana prema OUG 34/2014 (rumunjski/EU propisi o zaštiti potrošača), uz mogućnost eskalacije prema ANPC-u i alternativnog rješavanja sporova (SAL). Kontaktirajte nas na support@certapeptides.com.
Pravila o povratu →Informacije o proizvodu
Ovaj je proizvod namijenjen isključivo za znanstvena istraživanja i razvoj. Riječ je o kemijskoj tvari koja se ne smije upotrebljavati kao lijek, medicinski pripravak, djelatna tvar ni sastojak u bilo kojem proizvodu namijenjenom ljudskoj ili životinjskoj potrošnji. Istraživači moraju s ovim spojem rukovati u skladu sa smjernicama biološke sigurnosti svoje ustanove. Upotrebljavajte ga isključivo u primjereno opremljenim laboratorijskim uvjetima uz odgovarajuću osobnu zaštitnu opremu.
