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CertaPeptides

Certificate of Analysis

Third-party analytical testing report for research purposes only

VERIFIED

CP-COA-2602-5677

REP-2026-81101

Verify this certificate
certapeptides.com/verify → CP-2602-5677

Sample Information

Compound

Tirzepatide 5mg

Batch / Lot

CP-2602-5677

CAS Number

2023788-19-2

Label Claim

5 mg

Date Received

2026-01-26

Date Tested

2026-02-01

Date Issued

2026-02-05

Storage

Store at -20°C. Protect from light and moisture.

Appearance

White lyophilized powder, clear glass vial with aluminum crimp seal

Testing Laboratory

Analytical Sciences International (ASI)

Kurfuerstendamm 21, 10719 Berlin, Germany

Method

HPLC-UV (214nm) & ESI-MS

Analytical Results

Test
Method
Specification
Result
Status
General Appearance
USP <630>
White to off-white powder
Conforms
PASS
HPLC Purity Assay
USP <621>
>=99.0%
99.6%
PASS
HPLC Potency Assay
USP <621>
90-110% of 5 mg
5.3 mg (105.1%)
PASS
Identity (MS Confirmation)
USP <621>
Mass spectrum matches reference
ID Confirmed
PASS
Endotoxin (LAL)
USP <85>
<0.5 EU/mg
<0.22 EU/mg
PASS
Bioburden (TAMC/TYMC)
USP <61>
TAMC <100 CFU/g, TYMC <50 CFU/g
Conforms
PASS
Heavy Metals (ICP-MS)
USP <232>
Total <10 ppm; Pb <0.5, Cd <0.2, As <0.15, Hg <0.1 ppm
Conforms
PASS
Residual Solvents (GC-HS)
ICH Q3C / USP <467>
ACN <410 ppm, TFA <5 ppm
Conforms
PASS

ALL TESTS PASS

All analytical parameters meet or exceed acceptance criteria.

Analytical Data

Tirzepatide 5mg — Batch CP-2602-5677

CP-COA-2602-5677 | Page 2 of 3

HPLC-UV Chromatogram

Tirzepatide 5mgRT: 6.745 min0123456789100255075100Retention Time (min)Response (%)HPLC-UV Chromatogram @ 214 nmPurity: 99.6% | Area: 20006 mAU·s | RT: 6.745 min

Retention Time

6.745 min

Peak Area

20006 mAU·s

Wavelength

214 nm

Chromatographic Purity

99.6%

Mass Spectrometry Identification

Molecular Weight (Theoretical)

4813.45 Da

Observed m/z

1605.46

Charge State

[M+3H]3+

Identity

Confirmed

Interpretation: The observed molecular ion [M+3H]3+ at m/z 1605.46 is consistent with the theoretical molecular weight of 4813.45 Da for Tirzepatide 5mg (CAS 2023788-19-2). Mass spectrum matches reference standard within acceptable instrument variance (\u00B10.2 Da).

Methods & Authorization

Tirzepatide 5mg — Batch CP-2602-5677

CP-COA-2602-5677 | Page 3 of 3

Analytical Methods

USP <621>

Purity and potency determined by reversed-phase high-performance liquid chromatography (RP-HPLC) with UV detection at 214 nm and electrospray ionization mass spectrometry (ESI-MS) for identity confirmation. A C18 column (4.6 x 150 mm, 5 µm) was used with a linear gradient of water and acetonitrile, both containing 0.1% trifluoroacetic acid (TFA). Flow rate: 1.0 mL/min. Column temperature: 25°C. Injection volume: 10 µL.

USP <85>

Bacterial endotoxins test performed using the Limulus Amebocyte Lysate (LAL) kinetic turbidimetric method. Sensitivity: 0.01 EU/mL. Standard curve range: 0.01–1.0 EU/mL. Positive product control (PPC) spike recovery: 50–200%. All controls within acceptance criteria.

USP <61>

Microbial enumeration (bioburden) determined by membrane filtration per USP <61>. Total Aerobic Microbial Count (TAMC) on Soybean-Casein Digest Agar incubated at 30–35°C for 3–5 days. Total Yeast and Mold Count (TYMC) on Sabouraud Dextrose Agar incubated at 20–25°C for 5–7 days.

USP <630>

Visual inspection of physical appearance, color, and form. Sample compared against reference description for the active pharmaceutical ingredient.

Authorization

Dr. Maria Vasquez, M.Sc.

Analyst

Signed digitally on 2026-02-05

Dr. Thomas Bergmann, Ph.D.

Laboratory Director

Signed digitally on 2026-02-05

DISCLAIMER: This Certificate of Analysis is provided for research and informational purposes only. The products described herein are intended solely for in-vitro research and laboratory use. They are not intended for human or veterinary use, food, cosmetic, or household applications. The analytical data reported in this document pertains only to the specific batch/lot identified above and should not be extrapolated to other batches. CertaPeptides (CERTALAB S.R.L.) makes no warranties regarding the fitness of these products for any particular purpose beyond research applications. Results are valid for the batch number specified. Verify authenticity at certapeptides.com/verify.

CertaPeptides — CERTALAB S.R.L.
CP-COA-2602-5677